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  1. Article

    Open Access

    MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

    Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advance...

    C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson… in Nature Communications (2021)

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  2. Article

    Open Access

    PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer

    Novel drugs like Abiraterone or Enzalutamide, which target androgen receptor (AR) signaling to improve androgen deprivation therapy (ADT), have been developed during the past years. However, the application of...

    M Puhr, J Hoefer, A Eigentler, D Dietrich, G van Leenders, B Uhl, M Hoogland… in Oncogene (2016)

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  3. Article

    Open Access

    EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205

    Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpC...

    P Massoner, T Thomm, B Mack, G Untergasser, A Martowicz… in British Journal of Cancer (2014)

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