74 Result(s)
within
Greet Van den Berghe
English
Emergency Medicine
Intensive / Critical Care Medicine
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Article
Open AccessIntermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
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Open AccessDevelopment and validation of the creatinine clearance predictor machine learning models in critically ill adults
In critically ill patients, measured creatinine clearance (CrCl) is the most reliable method to evaluate glomerular filtration rate in routine clinical practice and may vary subsequently on a day-to-day basis....
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Article
Open AccessPersonalized nutrition therapy in critical care: 10 expert recommendations
Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose ente...
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Open AccessThe association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies
Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the interven...
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Open AccessToward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?
Although numerous observational studies associated underfeeding with poor outcome, recent randomized controlled trials (RCTs) have shown that early full nutritional support does not benefit critically ill pati...
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Open AccessImpact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial
Many critically ill children face long-term developmental impairments. The PEPaNIC trial attributed part of the problems at the level of neurocognitive and emotional/behavioral development to early use of pare...
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Article
C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery
Withholding parenteral nutrition (PN) early in critical illness, late-PN, has shown to prevent infections despite a higher peak C-reactive protein (CRP). We investigated whether the accentuated CRP rise was ca...
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Open AccessHyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?
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Open AccessPersisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness
Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...
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Open AccessA guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice
The preferential use of the oral/enteral route in critically ill patients over gut rest is uniformly recommended and applied. This article provides practical guidance on enteral nutrition in compliance with re...
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Article
Adrenal function/dysfunction in critically ill patients: a concise narrative review of recent novel insights
The “fight or flight” response to critical illness relies on increased cortisol availability, traditionally attributed to several-fold-increased cortisol production via hypothalamus–pituitary–adrenal-axis acti...
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Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study
To evaluate aerobic exercise capacity in 5-year intensive care unit (ICU) survivors and to assess the association between severity of organ failure in ICU and exercise capacity up to 5-year follow-up.
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Open AccessImpact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients
Recent evidence suggests a potentially protective effect of increasing ketone body availability via accepting low macronutrient intake early after onset of critical illness. The impact of blood glucose control...
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Open AccessAltered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate
Muscle weakness is a complication of critical illness which hampers recovery. In critically ill mice, supplementation with the ketone body 3-hydroxybutyrate has been shown to improve muscle force and to normal...
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Open AccessTargeted treatment of iron deficiency in prolonged critical illness: an opportunity to improve survival or not?
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Open AccessImpact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome
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Open AccessThe role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ W...
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Weakness in the ICU: the right weight on the right scale
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Intensive care unit acquired muscle weakness in COVID-19 patients
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Open AccessThe clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults
Circulating growth-differentiation factor-15 (GDF15), a cellular stress marker, abruptly increases during critical illness, but its later time course remains unclear. GDF15 physiologically controls oral intake...
