-
Article
Open AccessEfficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness
In septic mice, 3-hydroxybutyrate-sodium-salt has shown to partially prevent sepsis-induced muscle weakness. Although effective, the excessive sodium load was toxic. We here investigated whether ketone ester 3...
-
Article
Open AccessIdentification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice
In septic mice, supplementing parenteral nutrition with 150 mg/day 3-hydroxybutyrate-sodium-salt (3HB-Na) has previously shown to prevent muscle weakness without obvious toxicity. The main objective of this st...
-
Article
Open AccessThe role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ W...
-
Article
Open AccessAdipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle...
-
Article
Open AccessThe Role of Autophagy in Critical Illness-induced Liver Damage
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress, which activates the unfolded protein response (UPR), mediate critical illness-induced organ failure, often affecting the liver. Autophagy is kno...
