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  1. No Access

    Article

    Microbial ligand-independent regulation of lymphopoiesis by NOD1

    Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidogly...

    Chiaki Iwamura, Hidetaka Ohnuki, Francis A. Flomerfelt, Lixin Zheng… in Nature Immunology (2023)

  2. No Access

    Protocol

    Bone Marrow and Fetal Liver Radiation Chimeras

    Radiation chimeras are prepared by subjecting recipient mice to sublethal or lethal dose of irradiation and injecting them with hematopoietic stem cells (HSC) from untreated donor mice. HSC can be obtained fro...

    Francis A. Flomerfelt, Ronald E. Gress in T-Cell Development (2016)

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    Protocol

    Analysis of Cell Proliferation and Homeostasis Using EdU Labeling

    Determination of cellular proliferation and population turnover is an important tool for research on lymphoid cell function. Historically this has been done using radiolabeled nucleotides or nucleoside analogs...

    Francis A. Flomerfelt, Ronald E. Gress in T-Cell Development (2016)

  4. No Access

    Article

    Cadmium produces a delayed mitogenic response and modulates the EGF response in quiescent NRK cells

    Recent studies have shown that cadmium, at subtoxic levels, may induce a response characteristic of that elicited by a type of growth factor that supports the anchorage independent growth of cells that are not...

    M. Duane Enger, Francis A. Flomerfelt, Piper L. Wall… in Cell Biology and Toxicology (1987)