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  1. No Access

    Article

    Microbial ligand-independent regulation of lymphopoiesis by NOD1

    Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidogly...

    Chiaki Iwamura, Hidetaka Ohnuki, Francis A. Flomerfelt, Lixin Zheng… in Nature Immunology (2023)

  2. No Access

    Protocol

    Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling

    Angiogenesis identifies the process of endothelial cell sprouting and remodeling leading to the formation of new and functional blood vessels. Vascular expansion during development and in the adult mammal prov...

    Hidetaka Ohnuki, Giovanna Tosato in Semaphorin Signaling (2017)

  3. Article

    Open Access

    EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta

    Adult-type intraembryonic hematopoiesis arises from specialized endothelial cells of the dorsal aorta (DA). Despite the critical importance of this specialized endothelium for establishment of hematopoietic st...

    Inn-Inn Chen, Arianna Caprioli, Hidetaka Ohnuki, Hyeongil Kwak… in Scientific Reports (2016)

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  4. No Access

    Article

    EphrinB2 controls vessel pruning through STAT1-JNK3 signalling

    Angiogenesis produces primitive vascular networks that need pruning to yield hierarchically organized and functional vessels. Despite the critical importance of vessel pruning to vessel patterning and function...

    Ombretta Salvucci, Hidetaka Ohnuki, Dragan Maric, Xu Hou, Xuri Li… in Nature Communications (2015)