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Article
Open AccessEngineering non-conventional yeast Rhodotorula toruloides for ergothioneine production
Ergothioneine (EGT) is a distinctive sulfur-containing histidine derivative, which has been recognized as a high-value antioxidant and cytoprotectant, and has a wide range of applications in food, medical, and...
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Article
Preparation of Environmental Probiotic Factor γ-Polyglutamic Acid via Microbial Fermentation Using Baijiu Brewing Steamer Bottom Water as a Basic Substrate
Steamer bottom water is the main component of wastewater in the Baijiu industry, Find a suitable method to deal with and use the Steamer bottom water. A new, cheap raw material and process of γ-PGA production ...
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Article
Open AccessCRISPR/Cas9-based toolkit for rapid marker recycling and combinatorial libraries in Komagataella phaffii
Komagataella phaffii, a nonconventional yeast, is increasingly attractive to researchers owing to its posttranslational modification ability, strict methanol regulatory mechanism, and lack of Crabtree effect. Alt...
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Article
Open AccessDiagnostic value of cerebrospinal fluid Neutrophil Gelatinase-Associated Lipocalin for differentiation of bacterial meningitis from tuberculous meningitis or cryptococcal meningitis: a prospective cohort study
The early differential diagnosis between bacterial meningitis (BM) and tuberculous meningitis (TBM) or cryptococcal meningitis (CM) remains a significant clinical challenge. Neutrophil Gelatinase-Associated Li...
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Article
Generation and functional analysis of single chain variable fragments (scFvs) targeting the nucleocapsid protein of Porcine epidemic diarrhea virus
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, which can cause death in suckling piglets. Vaccines confer only partial protection against new mutant strains, whereas a...
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Chapter
Utilizing Patient Navigators to Promote Equitable and Accountable Research
Over the past decade, studies have shown that patient navigators (PNs) are effective at hel** clinical care teams address heath care barriers and improve health outcomes through a patient-centered approach; ...
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Article
Efficient CRISPR/Cas9-mediated genome editing in Rehmannia glutinosa
Here, we cloned a phytoene desaturase (PDS) gene from Rehmannia glutinosa, and realized RgPDS1 knock out in R. glutinosa resulted in the generation of albino plants.
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Article
Characterization of a novel halotolerant esterase from Chromohalobacter canadensis isolated from salt well mine
A esterase gene was characterized from a halophilic bacterium Chromohalobacter canadensis which was originally isolated from a salt well mine. Sequence analysis showed that the esterase, named as EstSHJ2, contain...
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Article
Metabolic engineering of an industrial Aspergillus niger strain for itaconic acid production
Itaconic acid is a value-added organic acid that is widely applied in industrial production. It can be converted from citric acid by some microorganisms including Aspergillus terreus and Aspergillus niger. Becaus...
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Article
Open AccessPlasticity without dislocations in a polycrystalline intermetallic
Dislocation activity is critical to ductility and the mechanical strength of metals. Dislocations are the primary drivers of plastic deformation, and their interactions with each other and with other microstru...
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Article
Identification of phytotoxic metabolites released from Rehmannia glutinosa suggest their importance in the formation of its replant problem
The yield and quality of medicinal tubers of Rehmannia glutinosa are seriously restricted by replanting problems. However, the origin and identification of the potential allelochemicals associated with this issue...
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Article
The preparation and therapeutic roles of scFv-Fc antibody against Staphylococcus aureus infection to control bovine mastitis
Staphylococcus aureus–induced bovine mastitis causes significant losses to the dairy industry and available vaccines do not confer adequate protection. As a more attractive alternative, we propose the use of anti...
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Article
Open AccessIdentification of Differentially Expressed Non-coding RNA in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs Responded to PRRSV
Porcine reproductive and respiratory syndrome (PRRS) is one of the most ruinous diseases in pig production. Our previous work showed that Tongcheng pigs (TC) were less susceptible to PRRS virus (PRRSV) than La...
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Article
Open AccessPolymorphism and plasma levels of apolipoprotein E and the risk of aneurysmal subarachnoid hemorrhage in a Chinese population: a case-control study
Aneurysmal subarachnoid hemorrhage (aSAH) is the most common types of subarachnoid hemorrhage, which is a critical clinical problem with high morbidity, mortality, and economic impact. Recent studies have show...
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Article
Open AccessNovel Application of Magnetic Protein: Convenient One-Step Purification and Immobilization of Proteins
Recently, a magnetic protein was discovered, and a multimeric magnetosensing complex was validated, which may form the basis of magnetoreception. In this study, the magnetic protein was firstly used in biotech...
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Article
Open AccessDifferential proteomic analysis of replanted Rehmannia glutinosa roots by iTRAQ reveals molecular mechanisms for formation of replant disease
The normal growth of Rehmannia glutinosa, a widely used medicinal plant in China, is severely disturbed by replant disease. The formation of replant disease commonly involves interactions among plants, allelochem...
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Article
Transcriptome analysis reveals metabolic alteration due to consecutive monoculture and abiotic stress stimuli in Rehamannia glutinosa Libosch
We deeply investigated the mechanism underlying metabolic regulation in response to consecutive monoculture (replanting disease) and different abiotic stresses that unfolded the respon...
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Article
A composite monolithic column fabricated with functionalized nanodiamond and its application in separation of small molecules
A nanodiamond-based composite monolithic column was fabricated by redox initiation for high performance liquid chromatography (HPLC). The functionalized nanodiamond was modified via Fenton Reagent and 3-methac...
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Chapter and Conference Paper
Preparation and DSC Analysis of γ-Poly Glutamic Acid Ester
With the increasing utilization of plastic in packaging industry, plastic waste caused great impact on the environment. So the research and development of new materials of biodegradable plastics could alleviat...
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Article
Open AccessSafety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors
Anlotinib is a novel multi-target tyrosine kinase inhibitor that is designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed to evaluate the safety, pharmacokinetics, and antitumor ...
