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  1. No Access

    Article

    Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer

    Severe combined immunodeficiency (SCID) patients with an inactivating mutation in recombination activation gene 1 (RAG1) lack B and T cells due to the inability to rearrange immunoglobulin (Ig) and T-cell recepto...

    K Pike-Overzet, M Rodijk, Y-Y Ng, M R M Baert, C Lagresle-Peyrou, A Schambach… in Leukemia (2011)

  2. No Access

    Article

    Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK

    X-linked agammaglobulinemia (XLA) is the most common primary immunodeficiency (PID) in man and caused by mutations in the Bruton’s tyrosine kinase (BTK) gene. XLA is characterized by a B-cell differentiation arre...

    Y Y Ng, M R M Baert, K Pike-Overzet, M Rodijk, M H Brugman, A Schambach, C Baum… in Leukemia (2010)

  3. No Access

    Article

    Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy

    The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL)...

    K Pike-Overzet, D de Ridder, F Weerkamp, M R M Baert, M M A Verstegen… in Leukemia (2007)

  4. Article

    Erratum: DNA microarrays for comparison of gene expression profiles between diagnosis and relapse in precursor-B acute lymphoblastic leukemia: choice of technique and purification influence the identification of potential diagnostic markers

    Correction to: Leukemia (2003) 17, 1324–1332. doi:10.1038/sj.leu.2402974 The authors would like to remark that, due to editorial changes in the above article, some references were accidentally switched. Refere...

    F J T Staal, M van der Burg, L F A Wessels, B H Barendregt, M R M Baert… in Leukemia (2004)

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  5. No Access

    Article

    DNA microarrays for comparison of gene expression profiles between diagnosis and relapse in precursor-B acute lymphoblastic leukemia: choice of technique and purification influence the identification of potential diagnostic markers

    Microarrays for gene expression profiling are rapidly becoming important research tools for the identification of novel markers, for example, for novel classification of leukemias and lymphomas. Here, we revie...

    F J T Staal, M van der Burg, L F A Wessels, B H Barendregt, M R M Baert… in Leukemia (2003)

  6. Article

    Open Access

    A novel germline mutation of PTEN associated with brain tumours of multiple lineages

    We have identified a novel germline mutation in the PTEN tumour suppressor gene. The mutation was identified in a patient with a glioma, and turned out to be a heterozygous germline mutation of PTEN (Arg234Gln...

    F J T Staal, R B van der Luijt, M R M Baert, J van Drunen… in British Journal of Cancer (2002)

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  7. Article

    Development of Immune Functions Related to Allergic Mechanisms in Young Children

    The newborn immune system differs quantitatively and functionally from that of adults. Development of the immune system has important implications for childhood diseases. The immaturity of the immune system in...

    H Koning, M R M Baert, A P Oranje, H F J Savelkoul, H J Neijens in Pediatric Research (1996)

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  8. No Access

    Article

    Evaluation of in vivo and in vitro repopulation assays for murine haemopoietic stem cells

    Three assays to determine the repopulation potential of stem cells in murine bone marrow grafts were evaluated on their reliability with regard to the ranges in graft size. In vivo, marrow repopulating ability...

    J. P. van der Sluijs, M. R. M. Baert… in Comparative Haematology International (1992)

  9. No Access

    Article

    Transferrin receptor expression and the regulation of placental iron uptake

    Placental transferrin receptors, located at the apical side of syncytiotrophoblast, mediate placental iron uptake. Regulation of transferrin receptors on the fetal-maternal exchange area could be a major deter...

    M. B. Bierings, M. R. M. Baert, H. G. van Eijk… in Molecular and Cellular Biochemistry (1991)