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Open AccessA telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer
There are few effective treatments for small cell lung cancer (SCLC) underscoring the need for innovative therapeutic approaches. This study focuses on exploiting telomerase, a critical SCLC dependency as a th...
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Article
Open AccessComprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
Inhibition of RTK pathways in cancer triggers an adaptive response that promotes therapeutic resistance. Because the adaptive response is multifaceted, the optimal approach to blunting it remains undetermined....
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Article
Open AccessCell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed “variant” due to the loss of NE characteristics. In this study, we computed NE scores...
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Open AccessAuthor Correction: Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer
EGFR inhibition is an effective treatment in the minority of non-small cell lung cancer (NSCLC) cases harboring EGFR-activating mutations, but not in EGFR wild-type (EGFRwt) tumors. Here we demonstrate that EG...
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Article
Identification and characterization of an alternative cancer-derived PD-L1 splice variant
Therapeutic blockade of the PD-1/PD-L1 axis is recognized as an effective treatment for numerous cancer types. However, only a subset of patients respond to this treatment, warranting a greater understanding o...
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Article
Open AccessSuppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity
Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and...
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Open AccessErratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
Nature Communications 8: Article number: 14922 (2017); Published 7 April 2017; Updated 9 June 2017 The affiliation details for Hideo Watanabe are incorrect in this Article. The correct affiliation details for ...
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Open AccessLkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) ...
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Article
Open AccessAdaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly ...
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Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Nature 513, 110–114 (2014); doi:10.1038/nature13441 corrigendum Nature 519, 118 (2015); doi:10.1038/nature14149 In Extended Data Fig. 1b of this Letter, the photomicrographic images of the hepatoblast cells gr...
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Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Nature 513, 110–114 (2014); doi:10.1038/nature13441 In this Article, the last line of the Acknowledgements should read: J.M.L. and D.S. are supported by the Asociación Española Contra el Cáncer (AECC); this ha...
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Article
Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models
Close resemblance of murine and human trials is essential to achieve the best predictive value of animal-based translational cancer research. Kras-driven genetically engineered mouse models of non-small-cell lung...
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Article
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Gain-of-function mutations in isocitrate dehydrogenase (IDH) are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly cancer of the liver bile ducts; now mutant IDH is sho...
