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Chapter
Fetal Cardiovascular Physiology
Our understanding of fetal cardiovascular physiology has markedly increased in the last 50 years, with the introduction of suitable animal models. When studying the cardiovascular system before birth, the temp...
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Article
Open AccessMolecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation
In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnat...
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Article
Open AccessMaternal and fetal cardiovascular and metabolic effects of intra-operative uterine handling under general anesthesia during pregnancy in sheep
A cohort study of 6,500,000 human pregnancies showed an increased risk of adverse fetal outcomes following abdominal but not non-abdominal surgery under general anesthesia. This may be the consequence of uteri...
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Article
Open AccessImpaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington’s Disease
Recent evidence shows that the Huntington’s disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decl...
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Chapter and Conference Paper
Heart Disease Link to Fetal Hypoxia and Oxidative Stress
The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of develo** disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter re...
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Article
Statins prevent adverse effects of postnatal glucocorticoid therapy on the develo** brain in rats
Postnatal glucocorticoid therapy in the treatment of chronic lung disease benefits lung function, however it adversely affects brain development. We hypothesized that combined postnatal glucocorticoid and stat...
