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Article
Open AccessPerinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fe...
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Article
Open AccessPerinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
The hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exq...
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Article
Open AccessEarly administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the potential for early administration to optimise their therapeutic capacit...
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Article
Open AccessNeuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction
Early-onset fetal growth restriction (FGR) is associated with adverse outcomes. We hypothesised that maternal melatonin administration will improve fetal brain structure in FGR.
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Article
Open AccessEffects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets
The neurovascular unit (NVU) within the brain is a multicellular unit that synergistically acts to maintain blood–brain barrier function and meet cerebral metabolic demand. Recent studies have indicated disrup...
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Article
Open AccessProgressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep
Antenatal infection/inflammation is associated with disturbances in neuronal connectivity, impaired cortical growth and poor neurodevelopmental outcomes. The pathophysiological substrate that underpins these c...
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Article
Open AccessEndothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs
Fetal growth restriction (FGR) is associated with deficits in the develo** brain, including neurovascular unit (NVU) dysfunction. Endothelial colony forming cells (ECFC) can mediate improved vascular stabili...
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Article
Open AccessAcceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community
Neural stem cells (NSCs) have the potential to engraft and replace damaged brain tissue, repairing the damaged neonatal brain that causes cerebral palsy (CP). There are procedures that could increase engraftme...
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Article
Open AccessEffect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function
The use of CD34 + cell-based therapies has largely been focused on haematological conditions. However, there is increasing evidence that umbilical cord blood (UCB) CD34 + -derived cells have neuroregenerative ...
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Article
Open AccessInterleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antago...
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Article
Open AccessUmbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No stu...
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Article
Open AccessExcess cerebral oxygen delivery follows return of spontaneous circulation in near-term asphyxiated lambs
Hypoxic-ischaemia renders the neonatal brain susceptible to early secondary injury from oxidative stress and impaired autoregulation. We aimed to describe cerebral oxygen kinetics and haemodynamics immediately...
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Article
Open AccessNeurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs
Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neu...
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Article
Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep
Chorioamnionitis and fetal inflammation are principal causes of neuropathology detected after birth, particularly in very preterm infants. Preclinical studies show that umbilical cord blood (UCB) cells are neu...
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Article
Fetal growth restriction is associated with an altered cardiopulmonary and cerebral hemodynamic response to surfactant therapy in preterm lambs
Efficacy of surfactant therapy in fetal growth restricted (FGR) preterm neonates is unknown.
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Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia
Impaired cerebral autoregulation in preterm infants makes circulatory management important to avoid cerebral hypoxic–ischemic injury. Dobutamine is frequently used as inotropic treatment in preterm neonates, b...
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Article
Open AccessIn situ phase contrast X-ray brain CT
Phase contrast X-ray imaging (PCXI) is an emerging imaging modality that has the potential to greatly improve radiography for medical imaging and materials analysis. PCXI makes it possible to visualise soft-ti...
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Article
Open AccessEffects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury
It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent cause of chronic disability in children. Recently, hum...
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Article
Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options
Cerebral palsy is the most common cause of physical disability in children, and there is no cure. Umbilical cord blood (UCB) cell therapy for the treatment of children with cerebral palsy is currently being as...
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Article
Term vs. preterm cord blood cells for the prevention of preterm brain injury
White matter brain injury in preterm infants can induce neurodevelopmental deficits. Umbilical cord blood (UCB) cells demonstrate neuroprotective properties, but it is unknown whether cells obtained from prete...
