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Article
Open AccessUse of Remdesivir in children with COVID-19: report of an Italian multicenter study
COVID-19 is generally milder in children than in adults, however severe infection has been described in some patients. Few data are available on use of Remdesivir (RDV) in children, as most clinical trials foc...
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Open AccessApplication of the Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the empiric antibiotic treatment of febrile neutropenia in oncological paediatric patients: experience from two paediatric hospitals in Northern Italy
Guidelines about febrile neutropenia in paediatric patients are not homogeneous; the best empiric treatment of this condition should be driven by local epidemiology. The Weighted-Incidence Syndromic Combinatio...
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General Management of the Patient: Specific Aspects of Infectious Disease Supportive Care in Children
Many of the conditions requiring allogeneic HCT and related complications are similar in adults and children and are covered in other chapters of this handbook. However, there are a few exceptions where approa...
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Article
Acute pediatric encephalitis: etiology, course, and outcome of a 12-year single-center immunocompetent cohort
Encephalitis is an uncommon but severe disorder due to an inflammation of the brain parenchyma, usually diagnosed on clinical, laboratory, electroencephalographic, and neuroradiological features. New causes of...
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Open AccessProtection against MIS-C outweighs the risk of myocarditis after Covid-19 vaccination in children
From March 2020 to July 2022, in Liguria region (North-West Italy) incidence of MIS-C among pediatric patients infected by SARS-CoV-2 was 38.7/100.000, which is higher than that of myocarditis after COVID-19 v...
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Article
Balamuthia mandrillaris infection: report of 1st autochthonous, fatal case in Italy
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Open AccessItalian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children
Acute hematogenous osteomyelitis (AHOM) is an insidious infection of the bone that more frequently affects young males. The etiology, mainly bacterial, is often related to the patient’s age, but it is frequent...
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Open AccessOpportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).
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General Management of the Patient: Specific Aspects of Children
Many of the conditions requiring allo-HSCT and related complications are similar in adults and children and are covered in other chapters of this handbook.
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Risk factors associated with development and mortality by invasive fungal diseases in pediatric allogeneic stem cell transplantation. A pediatric subgroup analysis of data from a prospective study of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
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Article
Antifungal Prophylaxis in Children Receiving Antineoplastic Chemotherapy
The purpose of this study was to summarize data on available antifungal prophylaxis of invasive fungal disease (IFD) in children and when it should be administered during antineoplastic chemotherapy.
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Monitoring of Busulphan Concentrations in Children Undergone Hematopoietic Stem Cell Transplantation: Unicentric Experience over 10 years
The aim of this report is to describe the experience in the management of busulphan-based conditioning regimen administered before hematopoietic stem cell transplantation (HSCT) in children.
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Open AccessMonitoring adherence to guidelines of antibiotic use in pediatric pneumonia: the MAREA study
Children are the most vulnerable population exposed to the use of antibiotics often incorrectly prescribed for the treatment of infections really due to viruses rather than to bacteria. We designed the MAREA s...
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Article
Management of Lyme Disease in European Children: a Review for Practical Purpose
Lyme disease is a tick-borne zoonosis transmitted through a bite of a tick carrying a spirochete belonging to Borrelia species. In the last 20 years, the reported incidence of Lyme disease is increased by three t...
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Open AccessProceedings of the 23rd Paediatric Rheumatology European Society Congress: part two
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Fungal infections of the lung in children
Fungal infections of the lungs are relatively common and potentially life-threatening conditions in immunocompromised children. The role of imaging in children with lung mycosis is to delineate the extension o...
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Article
Resistance to oral antibiotics in 4569 Gram-negative rods isolated from urinary tract infection in children
To investigate antibiotic resistance among pathogens isolated from urines in a tertiary care children’s hospital in Italy. Retrospective analysis of prospectively collected data on antibiotic susceptibility of...
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Erratum: Predicting microbiologically defined infection in febrile neutropenic episodes in children: global individual participant data multivariable meta-analysis
Correction to: British Journal of Cancer (2016) 114, 623–630. doi:10.1038/bjc.2016.28; published online 8 March 2016 Upon publication of the above paper in the British Journal of Cancer, the authors identified...
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Open AccessPredicting microbiologically defined infection in febrile neutropenic episodes in children: global individual participant data multivariable meta-analysis
Risk-stratified management of fever with neutropenia (FN), allows intensive management of high-risk cases and early discharge of low-risk cases. No single, internationally validated, prediction model of the ri...
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Open AccessMicafungin for the treatment of proven and suspected invasive candidiasis in children and adults: findings from a multicenter prospective observational study
A multicenter observational study was conducted in Italy to assess the safety of micafungin in the daily clinical practice for the treatment of proven and suspected invasive candidiasis (IC), as well as to des...
