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Open AccessA multi-center study on the adaptability of a shared foundation model for electronic health records
Foundation models are transforming artificial intelligence (AI) in healthcare by providing modular components adaptable for various downstream tasks, making AI development more scalable and cost-effective. Fou...
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Article
Outcomes of chemotherapy-induced nausea and vomiting guideline adherence in pediatric and adult patients: a systematic review
This study describes chemotherapy-induced nausea and vomiting (CINV) control rates in pediatric and adult patients who did or did not receive guideline-consistent CINV prophylaxis.
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Healthcare professional perspectives following implementation of an infection management care pathway for pediatric patients with cancer: a qualitative study
The Pediatric Oncology Group of Ontario (POGO) supported an effort to implement infection management care pathways based on clinical practice guidelines, to improve the consistency of infection management in p...
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Article
Opportunities for Continuing Education by Hematology Societies Available to International Trainees
Continuing education in hematology is a key for stimulating the development around the world and improving patient outcomes. However, access to training and education is not equally distributed worldwide, and ...
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Article
Open AccessCharacterizing the limitations of using diagnosis codes in the context of machine learning for healthcare
Diagnostic codes are commonly used as inputs for clinical prediction models, to create labels for prediction tasks, and to identify cohorts for multicenter network studies. However, the coverage rates of diagn...
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Article
Open AccessSymptom management care pathway adaptation process and specific adaptation decisions
There is substantial heterogeneity in symptom management provided to pediatric patients with cancer. The primary objective was to describe the adaptation process and specific adaptation decisions related to sy...
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Article
Open AccessEHR foundation models improve robustness in the presence of temporal distribution shift
Temporal distribution shift negatively impacts the performance of clinical prediction models over time. Pretraining foundation models using self-supervised learning on electronic health records (EHR) may be ef...
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Article
Open AccessOxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts
The optimal thresholds for the initiation of invasive ventilation in patients with hypoxemic respiratory failure are unknown. Using the saturation-to-inspired oxygen ratio (SF), we compared lower versus higher...
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Article
Open AccessFeasibility of three times weekly symptom screening in pediatric cancer patients
Primary objective was to determine the feasibility of three times weekly symptom reporting by pediatric cancer patients for eight weeks.
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Article
Interventions for the prevention of acute phase chemotherapy-induced nausea and vomiting in adult and pediatric patients: a systematic review and meta-analysis
To identify effective and safe interventions to prevent acute phase chemotherapy-induced nausea and vomiting (CINV) in adult and pediatric patients.
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Article
Creating and adapting an infection management care pathway in pediatric oncology
While care pathways based upon clinical practice guidelines (CPGs) are important, little is known about optimal approaches to development and adaptation in pediatric oncology. Objectives were to develop care p...
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Open AccessReliability and validity of proxy-SSPedi and mini-SSPedi in pediatric patients 2-7 years receiving cancer treatments
Symptom Screening in Pediatrics Tool (SSPedi) was developed for symptom screening by children 8-18 years. Objectives were to evaluate the reliability and validity of proxy-SSPedi and self-report mini-SSPedi fo...
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Article
Open AccessRationale and design of Children’s Oncology Group (COG) study ACCL20N1CD: financial distress during treatment of acute lymphoblastic leukemia in the United States
The study purpose is to describe trajectories of financial distress for parents of children (ages 1–14.9 years) with newly diagnosed acute lymphoblastic leukemia (ALL). The secondary aim is to identify multile...
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Article
Open AccessPersonalized antibiograms for machine learning driven antibiotic selection
The Centers for Disease Control and Prevention identify antibiotic prescribing stewardship as the most important action to combat increasing antibiotic resistance. Clinicians balance broad empiric antibiotic c...
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Open AccessEvaluation of domain generalization and adaptation on improving model robustness to temporal dataset shift in clinical medicine
Temporal dataset shift associated with changes in healthcare over time is a barrier to deploying machine learning-based clinical decision support systems. Algorithms that learn robust models by estimating inva...
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Article
Identifying clinical practice guidelines for symptom control in pediatric oncology
Children with cancer commonly experience distressing symptoms such as pain, fatigue and nausea. Improvements in patient outcomes have been associated with implementation of clinical practice guideline-consiste...
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Article
Open AccessBarriers to symptom management care pathway implementation in pediatric Cancer
Objectives were to describe barriers to pediatric cancer symptom management care pathway implementation and the impact of the COVID-19 pandemic on clinical research evaluating their implementation.
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Open AccessFacilitators and barriers to clinical practice guideline-consistent supportive care at pediatric oncology institutions: a Children’s Oncology Group study
Clinical practice guideline (CPG)-consistent care improves patient outcomes, but CPG implementation is poor. Little is known about CPG implementation in pediatric oncology. This study aimed to understand suppo...
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Article
Reasons for disagreement between proxy-report and self-report rating of symptoms in children receiving cancer therapies
To qualitatively describe reasons for disagreement in ratings of bothersome symptoms between child self-report and parent proxy-report.
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Feeling scared or worried self-report in children receiving cancer treatments using the Symptom Screening in Pediatrics Tool (SSPedi)
The objectives of this study were to describe reports of bother for feeling scared or worried among children with cancer and pediatric hematopoietic stem cell transplant (HSCT) recipients, and to identify fact...
