-
Article
Open AccessTrajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, ...
-
Article
Open AccessEpigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking
Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung ...
-
Article
Open AccessTranscriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
Recent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from...
-
Article
Open AccessThe fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study
We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study,...
-
Article
Open AccessPredicting breast cancer metastasis from whole-blood transcriptomic measurements
In this exploratory work we investigate whether blood gene expression measurements predict breast cancer metastasis. Early detection of increased metastatic risk could potentially be life-saving. Our data come...
-
Article
Open AccessUse of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study
Concerns have been raised that extensive use of personal care products that contain endocrine disrupting compounds increase the risk of hormone sensitive cancers.
-
Article
Open AccessDifferential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study
MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast ca...
-
Article
Open AccessPhysical activity patterns and the risk of colorectal cancer in the Norwegian Women and Cancer study: a population-based prospective study
Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in m...
-
Article
Epigenome-wide association study of adiposity and future risk of obesity-related diseases
Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is n...
-
Article
Open AccessDNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort
The majority of lung cancer is caused by tobacco smoking, and lung cancer-relevant epigenetic markers have been identified in relation to smoking exposure. Still, smoking-related markers appear to mediate litt...
-
Article
Open AccessOsteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL)...
-
Article
Open AccessCharacterization of heavy users of skin care products among Norwegian women from 2003 to 2011
Several ingredients in personal care products (PCPs) have been classified as endocrine disruptors (EDs) and concern has been raised whether use of PCPs can affect human health. We aimed to characterize Norwegi...
-
Article
Coffee consumption and the risk of cancer in the Norwegian Women and Cancer (NOWAC) Study
An association between coffee consumption and cancer has long been investigated. Coffee consumption among Norwegian women is high, thus this is a favorable population in which to study the impact of coffee on ...
-
Article
Open AccessThe fraction of breast cancer attributable to smoking: The Norwegian women and cancer study 1991–2012
Results from several recent cohort studies on smoking and breast cancer incidence and mortality suggest that the burden of smoking on society is underestimated. We estimated the fraction of breast cancer attri...
-
Article
Open AccessModifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study
Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, ...
-
Article
Intake of whole grains and incidence of oesophageal cancer in the HELGA Cohort
Few prospective studies have investigated the association between whole-grain consumption and incidence of oesophageal cancer. In the Scandinavian countries, consumption of whole grains is high and the inciden...
-
Article
Open AccessA new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle
The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of g...
-
Article
Open AccessPhysical activity before and after breast cancer diagnosis and survival - the Norwegian women and cancer cohort study
The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast c...
-
Article
Open AccessHypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pr...
-
Article
Open AccessWhole-Blood Gene Expression Profiles in Large-Scale Epidemiological Studies: What Do They Tell?
In nutrigenomics, gene expression profiling is used to investigate transcriptional mechanisms associated with nutrients and diet. Blood samples collected in the framework of dietary interventions and epidemiol...
