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Article
A high-throughput pipeline for validation of antibodies
Western blotting (WB) is widely used to test antibody specificity, but the assay has low throughput and precision. Here we used preparative gel electrophoresis to develop a capture format for WB. Fractions wit...
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Article
Open AccessA new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle
The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of g...
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Article
Open AccessThe differential disease regulome
Transcription factors in disease-relevant pathways represent potential drug targets, by impacting a distinct set of pathways that may be modulated through gene regulation. The influence of transcription factor...
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Article
Open AccessThe Genomic HyperBrowser: inferential genomics at the sequence level
The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled...
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Article
Well Conditioning in Object Models
This paper presents two object models with corresponding simulation algorithms, which aim to condition well data correctly while still converging in reasonable time. The first model is devoted to fluvial chan...
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Article
Stochastic Structural Modeling
A consistent stochastic model for faults and horizons is described. The faults are represented as a parametric invertible deformation operator. The faults may truncate each other. The horizons are modeled as c...
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Article
Comment on Special Issue on Geostatistics with Guest Editor A. G. Journel
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Chapter
Semi-Markov Random Fields
The spatial distribution of sedimentary fades in petroleum reservoirs is of major concern due to its influence on the flow regime in the reservoir, and thereby the production of oil and gas. A class of stochas...
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Article
A tensor estimator for the homogenization of absolute permeability
An estimator for an effective permeability tensor based on one-phase incompressible flow is presented. Effective large-scale permeability tensors are well approximated by rough approximations to the fine-scale...
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Chapter and Conference Paper
On the Strict Hyperbolicity of the Buckley-Leverett Equations for Three-Phase Flow
It is proved that the standard assumptions on the Buckley-Leverett equations for three-phase flow imply that the equation system is not strictly hyperbolic. Therefore, the solution of the Buckley-Leverett equa...
