41 Result(s)
within
D. Tibboel
Pediatrics
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Article
Insights Image for “Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats”
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Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats
Prematurely born infants are frequently exposed to painful procedures in the neonatal intensive care unit, causing changes to the development of the nervous system lasting into adulthood. The current study aim...
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Changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation
Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO).
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Children’s outcomes at 2-year follow-up after 4 years of structured multi-professional medical-ethical decision-making in a neonatal intensive care unit
We reviewed our decisions about continuation/withdrawal of life-sustaining treatments in a group of critically ill newborns who were discussed in structured medical ethical decision-making meetings, and provid...
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Adverse events of haloperidol for the treatment of delirium in critically ill children
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Open AccessLumbar spine and total-body dual-energy X-ray absorptiometry in children with severe neurological impairment and intellectual disability: a pilot study of artefacts and disrupting factors
Children with severe neurological impairment and intellectual disability (ID) are susceptible for develo** low bone mineral density (BMD) and fractures. BMD is generally measured with dual-energy X-ray absor...
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Open AccessDeterminants of drug absorption in different ECMO circuits
The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits.
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144 Incidence, Risk Factors and Severity of Pulmonary Morbidity in Infants with Congenital Diaphragmatic Hernia Born in High-Volume Centres in Europe
Background and aims: Newborns with congenital diaphragmatic hernia (CDH) may develop chronic lung disease (CLD). Our aim was to determine the incidence, severity and risk factors of CLD in infants with CDH.
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Open AccessFeasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications. In ventilated adults not on ECMO, daily sedation interrup...
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Open AccessCan we improve outcome of congenital diaphragmatic hernia?
This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are descri...
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Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study
To develop novel therapies that prevent opioid tolerance in critically ill children we examined the effects of low-dose naloxone infusions on patients' needs for analgesia or sedation.
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Het kortedarmsyndroom
In 1987 publiceerden Tibboel en Affourtit in dit tijdschrift een overzichtsartikel over het kortedarmsyndroom bij kinderen. Zij concludeerden dat er na neonatale darmresectie een ernstige morbiditeit optreedt ...
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Evaluatie van resterende darmfunctie in de dagelijkse praktijk
When the digestive and absorptive capacity of the gastrointestinal tract are insufficient, as they are in patients with short bowel syndrome (sbs), systematic evaluation of the remaining gut function is of the ut...
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Nieuwe ontwikkelingen in de behandeling van het kortedarmsyndroom bij kinderen
Short bowel syndrome is characterized by malabsorption of nutrients, vitamins en trace elements, resulting in growth retardation. Children with short bowel syndrome are often dependent on total parenteral nutr...
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Het kortedarmsyndroom bij kinderen
Patients with short bowel syndrome suffer from malabsorption due to loss of functional intestinal mass. The incidence is not exactly known since many different definitions of the syndrome have been reported. T...
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Complicatieregistratie in de kindergeneeskundige praktijk
Complication registration is a major instrument for improving quality of healthcare. It may serve, first, to determine frequency and severity of complications, and next how to reduce incidences and severities.
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Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons
Oesophageal atresia and tracheo-oesophageal fistula are relatively frequently occurring foregut malformations of which the aetiology and pathogenesis are poorly understood. Recent results of molecular genetic ...
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7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates
Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...
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276 Neonates With Severe Respiratory Insufficiency Requiring ECMO Have Decreased Surfactant Synthesis
Background: Respiratory insufficiency in neonates with congenital diaphragmatic hernia (CDH), meconium aspiration syndrome (MAS) or other forms of persistent pulmonary hypertensin of the newborn (PPHN) is frequen...
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6 Impact of Administration of Analgesics During Neonatal Stay on Pain Expression Following Neonatal Stay in Former Preterm Infants
Introduction: There are still few data on the impact of pharmacologic treatment of pain during neonatal stay in preterm infants on pain expression after neonatal stay. We therefore investigated pain expression in...
