12 Result(s)

Article

Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis

Most cell death stimuli trigger the mitochondrial release of cytochrome c and other cofactors that induce caspase activation and ensuing apoptosis. Apoptosis is also associated with massive mitochondrial fragment...

J Estaquier, D Arnoult in Cell Death & Differentiation (2007)

Article

Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis

Cardiolipin (CL) is a mitochondria-specific phospholipid synthesized by CL synthase (CLS). We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. Although mitochond...

S-Y Choi, F Gonzalvez, G M Jenkins, C Slomianny, D Chretien… in Cell Death & Differentiation (2007)

Article

Apoptosis in SIV infection

Pathogenic human immunodeficiency virus (HIV)/Simian immunodeficiency virus (SIV) infection is associated with increased T-cell apoptosis. In marked contrast to HIV infection in humans and SIV infection in mac...

B Hurtrel, F Petit, D Arnoult, M Müller-Trutwin… in Cell Death & Differentiation (2005)

Article

A novel mechanism for HIV1-mediated bystander CD4+ T-cell death: neighboring dying cells drive the capacity of HIV1 to kill noncycling primary CD4+ T cells

CD4+ T-cell death is a crucial feature of AIDS pathogenesis, but the mechanisms involved remain unclear. Here, we present in vitro findings that identify a novel process of HIV1 mediated killing of bystander CD4+...

J D Lelièvre, F Mammano, D Arnoult, F Petit, A Grodet… in Cell Death & Differentiation (2004)

Article

Erratum: Caspase-dependent and -independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression

Corrrection to: Cell Death and Differentiation (2003) 10, 1240–1252. doi:10.1038/sj.cdd.4401289 Owing to a typesetting error, two author names were published incorrectly.

D Arnoult, F Petit, J D Lelièvie, D Lecossier, A Hance… in Cell Death & Differentiation (2004)

Article

Caspase-dependent and -independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression

Studies of human immunodeficiency virus (HIV) and nonhuman primate models of pathogenic and nonpathogenic simian immunodeficiency virus (SIV) infections have suggested that enhanced ex vivo CD4 T-cell death is a ...

D Arnoult, F Petit, J D Lelièvie, D Lecossier, A Hance… in Cell Death & Differentiation (2003)

Article

Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor

D Arnoult, M Karbowski, R J Youle in Cell Death & Differentiation (2003)

Article

On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

Leishmania major is a protozoan parasite from one of the most ancient phylogenic branches of unicellular eukaryotes, and containing only one giant mitochondrion. Here we report that staurosporine, that induces ap...

D Arnoult, K Akarid, A Grodet, P X Petit, J Estaquier… in Cell Death & Differentiation (2002)

Article

Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria

Human mature erythrocytes have been considered as unable to undergo programmed cell death (PCD), due to their lack of mitochondria, nucleus and other organelles, and to the finding that they survive two condit...

D Bratosin, J Estaquier, F Petit, D Arnoult, B Quatannens… in Cell Death & Differentiation (2001)