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Article
The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria
The proapoptotic Bcl-2 protein Bax can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane. Prosurvival Bcl-2 family member...
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Article
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1). Although Bax and Bak seem to have redundant roles ...
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Article
Bcl-2 family interaction with the mitochondrial morphogenesis machinery
The regulation of both mitochondrial dynamics and apoptosis is key for maintaining the health of a cell. Bcl-2 family proteins, central in apoptosis regulation, also have roles in the maintenance of the mitoch...
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Article
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a fo...
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Article
Which came first, the cytochrome c release or the mitochondrial fission?
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Article
Erratum: Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation
Cell Death and Differentiation (2004) 11, 1265–1276. doi:10.1038/sj.cdd.4401508 Since the publication of the above paper, the authors have identified an error in the author names. The correct listing is as fol...
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Article
Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation
In the present study, we evaluated proapoptotic protein Bax on mitochondria and Ca2+ homeostasis in primary cultured astrocytes. We found that recombinant Bax (rBax, 10 and 100 ng/ml) induces a loss in mitochondr...
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Article
Dynamics of mitochondrial morphology in healthy cells and during apoptosis
Mitochondria exist as dynamic networks that often change shape and subcellular distribution. The number and morphology of mitochondria within a cell are controlled by precisely regulated rates of organelle fus...
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Article
Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor
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Article
Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential
Bax, a pro-apoptotic member of the Bcl-2 family, is a cytosolic protein that inserts into mitochondrial membranes upon induction of cell death. Using the green fluorescent protein fused to Bax (GFP-Bax) to qua...
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Chapter
Immunotoxins for Brain Tumor Therapy
Cancer cells can be specifically killed by a class of therapeutic molecules called immunotoxins that combine the potent toxicity of natural plant and bacterial proteins with the tumor-specific binding capacity...
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Chapter
Genetic engineering of immunotoxins
Genetic engineering offers many advantages for the 1) production of immunotoxins (ITs) and 2) design of more effective reagents. In Chapter 9, J.R. Murphy discusses the use of genetic engineering to link genes...
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Chapter
Toxin selection and modification — Overview
A multitude of cell-type-specific toxins have been made by linking toxins to cell-surface binding moieties. This section focuses on the various toxins and toxin-related and toxin-derived proteins that have bee...
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Article
Monoclonal antibodies and immobilized antibodies
Antibodies in both their free and immobilized state have been the object of considerable industrial and academic interest. A variety of methods are used for preparing and immobilizing antibodies. Applications ...
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Article
Patents and literature
