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  1. Article

    On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

    Leishmania major is a protozoan parasite from one of the most ancient phylogenic branches of unicellular eukaryotes, and containing only one giant mitochondrion. Here we report that staurosporine, that induces ap...

    D Arnoult, K Akarid, A Grodet, P X Petit, J Estaquier… in Cell Death & Differentiation (2002)

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    Protective effect of Poly(A)-Poly(U) against immune oxidative injury. Role of thiols released by activated macrophages

    Various drugs with or without sulfur groups have been demonstrated to exert antioxidant properties in vivo. In this latter group immunomodulating agents such as the polyribonucleotide Poly(I)-Poly(C) have been...

    M. Fay, M. Jampy-Fay, K. Akarid… in Oxidative Stress, Cell Activation and Vira… (1994)