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  1. Article

    Open Access

    Non-viral precision T cell receptor replacement for personalized cell therapy

    T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells1–3. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision genome-editing to simultaneously...

    Susan P. Foy, Kyle Jacoby, Daniela A. Bota, Theresa Hunter, Zheng Pan… in Nature (2023)

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  2. No Access

    Article

    Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy

    Neoantigens are peptides derived from non-synonymous mutations presented by human leukocyte antigens (HLAs), which are recognized by antitumour T cells1–14. The large HLA allele diversity and limiting clinical sa...

    Cristina Puig-Saus, Barbara Sennino, Songming Peng, Clifford L. Wang, Zheng Pan… in Nature (2023)

  3. No Access

    Article

    Modulating ectopic gene expression levels by using retroviral vectors equipped with synthetic promoters

    The human cytomegalovirus and elongation factor 1α promoters are constitutive promoters commonly employed by mammalian expression vectors. These promoters generally produce high levels of expression in many ty...

    Joshua P. Ferreira, Ryan W. S. Peacock… in Systems and Synthetic Biology (2011)

  4. Article

    Open Access

    Slow, stochastic transgene repression with properties of a timer

    When gene expression varies unpredictably between genetically identical organisms, this is sometimes ascribed as stochastic. With the prevalence of retroviral vectors, stochastic repression is often observed a...

    Clifford L Wang, Desirée C Yang, Matthias Wabl in Genome Biology (2006)

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  5. No Access

    Article

    Mutational activity in cell line WEHI-231

    The cell line WEHI-231 expresses activation-induced cytidine deaminase (AID), the enzyme that mediates hypermutation and immunoglobulin class switch recombination in activated B cells. Although both the cDNA s...

    Clifford L. Wang, Matthias Wabl in Immunogenetics (2005)

  6. Article

    Open Access

    A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

    To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen… in Retrovirology (2004)

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  7. No Access

    Article

    A deep-sea hydrothermal vent isolate, Pseudomonas aeruginosa CW961, requires thiosulfate for Cd2+ tolerance and precipitation

    Pseudomonas aeruginosa CW961, an isolate from the vicinity of a deep-sea hydrothermal vent, grew in the presence of 5 mM Cd2+ and removed Cd2+ from solution. Sulfate was sufficient for growth when Cd2+ was not p...

    Clifford L. Wang, Samantha C. Ozuna, Douglas S. Clark… in Biotechnology Letters (2002)