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  1. No Access

    Article

    microRNAs in Gliomas: Small Regulators of a Big Problem

    Gliomas are the most common form of primary brain tumors and are associated with a poor clinical outcome. The molecular mechanisms that contribute to gliomagenesis have become increasingly clear in recent year...

    Joachim Silber, C. David James, J. Graeme Hodgson in NeuroMolecular Medicine (2009)

  2. Article

    Open Access

    miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

    Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular and cellular mechanisms that d...

    Joachim Silber, Daniel A Lim, Claudia Petritsch, Anders I Persson… in BMC Medicine (2008)

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  3. Article

    Open Access

    Mammary carcinoma behavior is programmed in the precancer stem cell

    The 'MINO' (mammary intraepithelial neoplasia outgrowth) mouse model of ductal carcinoma in situ (DCIS) consists of six lines with distinct morphologic phenotypes and behavior, each meeting experimentally defined...

    Patrizia Damonte, J Graeme Hodgson, Jane Qian Chen… in Breast Cancer Research (2008)

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  4. No Access

    Article

    Syngeneic mouse mammary carcinoma cell lines: Two closely related cell lines with divergent metastatic behavior

    Two cell lines, Met-1fvb2 and DB-7fvb2, with different metastatic potential, were derived from mammary carcinomas in FVB/N-Tg(MMTV-PyVmT) and FVB/N-Tg(MMTV-PyVmT Y315F/Y322F ...

    Alexander D. Borowsky, Ruria Namba… in Clinical & Experimental Metastasis (2005)

  5. Article

    Open Access

    A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

    To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen… in Retrovirology (2004)

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  6. No Access

    Article

    Genome Amplification of Chromosome 20 in Breast Cancer

    Recurrent gain and amplification of the long arm of chromosome 20 (20q) has been observed in a wide variety of cancers. This suggests that a gene or genes encoded on 20q play important roles in contributing to...

    J. Graeme Hodgson, Koei Chin, Colin Collins… in Breast Cancer Research and Treatment (2003)