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Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection

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Abstract

The development of transition metal complex-based luminescent chemosensors has recently aroused increasing interest for protein biomarker labelling and detection, especially for the real-time diagnosis and treatment of disease. This is owing to their unique photophysical properties, particularly their long-lived and environmentally sensitive emission, which can be easily controlled via the structural modification of ligands. In this overview, we highlight recent examples of protein biomarker detection using group 8–9 metal-based luminescent chemosensors, including the frequently employed ruthenium(II) and iridium(III) complexes. Various mechanisms and sensing modes are described and compared, and the outlook and future directions of this field are discussed as well.

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Acknowledgements

This work is supported by Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522, 14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121, 21775131 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS).

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  1. Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

    Dik‐Lung Ma & Chun Wu

  2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China

    Guodong Li & Chung‐Hang Leung

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  1. Dik‐Lung Ma
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  2. Chun Wu
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Correspondence to Dik‐Lung Ma or Chung‐Hang Leung.

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Ma, D., Wu, C., Li, G. et al. Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection. J. Anal. Test. 2, 77–89 (2018). https://doi.org/10.1007/s41664-017-0045-1

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