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Article
Open AccessKDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The clinical subtypes of BC include estrogen receptor (ER) positive, progesterone receptor...
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Article
Synthesis and luminescence monitoring of iridium(III) complex-functionalized gold nanoparticles and their application for determination of gold(III) ions
A new method is presented for the one-step synthesis and real-time monitoring of iridium(III) complex-functionalized AuNPs from the precursor gold(III) chloride (AuCl3). The functionalized AuNPs with an average s...
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Article
Open AccessHomocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing....
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Article
Open AccessA small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilize...
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Article
Open AccessCorrection to: The design and development of covalent protein-protein interaction inhibitors for cancer treatment
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessThe design and development of covalent protein-protein interaction inhibitors for cancer treatment
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibiti...
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Article
Open AccessAnticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction
The hypoxia inducible factor (HIF) pathway has been considered to be an attractive anti-cancer target. One strategy to inhibit HIF activity is through the disruption of the HIF-1α–p300 protein-protein interact...
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Article
Open AccessAntagonizing STAT5B dimerization with an osmium complex
Targeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first metal-based inhibitor of STAT5B di...
