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Article
Urine DNA biomarkers for hepatocellular carcinoma screening
Hepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve sensitivity and efficacy. Therefore, we investigated the use of urine circ...
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Article
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2
The poor prognosis and recurrence of HCC are majorly caused by intrahepatic metastasis. Delineating the molecular pathways mediating these processes may benefit develo** effective targeting therapies. Using ...
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Book
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Chapter
Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways
In the tumor microenvironment, the primary tumor cells may recruit and interact with stromal cells and inflammatory cells including macrophages, mast cells and neutrophiles. A great multitude of growth factors...
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Chapter
Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression
Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling in...
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Article
Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species
Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling in...