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  1. Article

    Open Access

    Novel urine cell-free DNA methylation markers for hepatocellular carcinoma

    An optimized hepatocellular carcinoma (HCC)-targeted methylation next generation sequencing assay was developed to discover HCC-associated methylation markers directly from urine for HCC screening. Urine cell-...

    Selena Y. Lin, Wei **a, Amy K. Kim, Dion Chen, Shelby Schleyer… in Scientific Reports (2023)

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  2. No Access

    Chapter

    NGS Analysis of Plasma cfDNA and cfmiRNA Signatures in Melanoma Brain Metastasis Patients

    Cutaneous melanoma patients suffer from poor prognosis particularly when the disease has spread to the brain. Hence, it is critical the early detection and diagnosis of melanoma brain metastasis (MBM). Molecul...

    Romela Irene Ramos, Selena Y. Lin, Matias A. Bustos… in Circulating Tumor Cells (2023)

  3. No Access

    Article

    Urine DNA biomarkers for hepatocellular carcinoma screening

    Hepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve sensitivity and efficacy. Therefore, we investigated the use of urine circ...

    Amy K. Kim, James P. Hamilton, Selena Y. Lin, Ting-Tsung Chang… in British Journal of Cancer (2022)

  4. Article

    Open Access

    Characterization of the hepatitis B virus DNA detected in urine of chronic hepatitis B patients

    Detection of human hepatitis B virus (HBV) DNA in the urine of patients with chronic hepatitis B infection (CHB) has been reported previously, suggesting urine could provide a potential route of horizontal HBV...

    Surbhi Jain, Ying-Hsiu Su, Yih-** Su, Sierra McCloud, Ruixia Xue… in BMC Gastroenterology (2018)

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  5. No Access

    Chapter

    Detection of Minimal Residual Disease and Its Clinical Applications in Melanoma and Breast Cancer Patients

    Melanoma and breast cancer (BC) patients face a high risk of recurrence and disease progression after curative surgery and/or therapeutic treatment. Monitoring for minimal residual disease (MRD) during a disea...

    Selena Y. Lin, Javier I. J. Orozco… in Biological Mechanisms of Minimal Residual … (2018)

  6. No Access

    Article

    Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence

    Amplification of chromosome 1q21.3 distinguishes cells with tumor-initiating capacity that drive tumor recurrence across different breast cancer subtypes. A droplet digital PCR assay in circulating free tumor ...

    Jian Yuan Goh, Min Feng, Wenyu Wang, Gokce Oguz, Siti Maryam J M Yatim… in Nature Medicine (2017)

  7. Article

    Open Access

    Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues

    Hepatitis B virus (HBV) is a hepatotropic virus causing hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The methylation status of the HBV DNA in its different forms can potentially provide insight int...

    Surbhi Jain, Ting-Tsung Chang, Sitong Chen, Batbold Boldbaatar… in Scientific Reports (2015)

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