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  1. No Access

    Article

    Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats

    The effects of exercise on the heart and its resistance to disease are well-documented. Recent studies have identified that exercise-induced resistance to arrhythmia is due to the preservation of mitochondrial...

    Traci L. Parry, Joseph W. Starnes, Sara K. O’Neal, James R. Bain… in Metabolomics (2017)

  2. No Access

    Article

    Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates

    The ubiquitin–proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, a...

    Carrie E. Rubel, Jonathan C. Schisler, Eric D. Hamlett… in Cell Biochemistry and Biophysics (2013)

  3. No Access

    Protocol

    Reconstitution of CHIP E3 Ubiquitin Ligase Activity

    CHIP, the carboxyl-terminus of Hsp70 interacting protein, is both an E3 ubiquitin ligase and an Hsp70 co-chaperone and is implicated in the degradation of cytosolic quality control and numerous disease substra...

    Hong Yu Ren, Cam Patterson, Douglas M. Cyr, Meredith F. N. Rosser in Molecular Chaperones (2011)

  4. No Access

    Chapter

    The Role of Thrombin in Vascular Development

    Vasculogenesis is essential for embryonic development. The vasculature and the intravascular blood compartment develop in a close spatial and temporal relationship. Here we discuss how thrombin, as the common ...

    Martin Moser, Cam Patterson* in Thrombin (2009)

  5. No Access

    Article

    Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

    Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via a mechanism distinct from other Hsp70 nucleotide-...

    Zhen Xu, Richard C Page, Michelle M Gomes… in Nature Structural & Molecular Biology (2008)

  6. No Access

    Chapter

    Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP

    Following exposure to environmental insults, the cells in most tissues dramatically increase the production of a group of proteins that are collectively known as “heat shock” or stress proteins (Parsell and Lindq...

    Shu-Bing Qian, Cam Patterson in Cell Stress Proteins (2007)

  7. No Access

    Protocol

    Cystic Fibrosis Transmembrane Conductance Regulator as a Model Substrate to Study Endoplasmic Reticulum Protein Quality Control in Mammalian Cells

    Components of the ubiquitin-proteasome system function on the surface of the endoplasmic reticulum (ER) to select misfolded proteins for degradation. Herein we describe methods that allow for the study of the ...

    J. Michael Younger, Chun-Yang Fan, Liling Chen… in Ubiquitin-Proteasome Protocols (2005)

  8. No Access

    Article

    Shear Stress Reduces Protease Activated Receptor-1 Expression in Human Endothelial Cells

    Shear stress has been shown to regulate several genes involved in the thrombotic and proliferative functions of endothelial cells. Thrombin receptor (protease-activated receptor-1: PAR-1) increases at sites of...

    Kytai Truong Nguyen, Suzanne G. Eskin, Cam Patterson… in Annals of Biomedical Engineering (2001)

  9. No Access

    Article

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB (NF-κB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqui Han… in Molecular and Cellular Biochemistry (2000)

  10. No Access

    Chapter

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-кB (NF-кB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqi Han… in Control of Gene Expression by Catecholamin… (2000)