83 Result(s)

Article

von Willebrand factor and early diabetic retinopathy: no evidence for a relationship in patients with Type 1 (insulin-dependent) diabetes mellitus and normal urinary albumin excretion

High plasma levels of von Willebrand factor, an indicator of endothelial cell dysfunction, have been reported in both diabetic retinopathy and nephropathy. It is unclear, however, whether von Willebrand factor...

C. D. A. Stehouwer, P. Zellenrath, B. C. P. Polak, G. S. Baarsma… in Diabetologia (1992)

Article

Effects of insulin infusion on endothelium-derived vasoactive substances

An association between insulin resistance and hypertension has been reported in several studies. In apparent contradiction, insulin infusion in healthy volunteers is associated with vasodilatation. Furthermor...

K. H. Polderman, C. D. A. Stehouwer, G. J. van Kamp, L. J. G. Gooren in Diabetologia (1996)

Article

Heterogeneous nature of microalbuminuria in NIDDM: studies of endothelial function and renal structure

Microalbuminuria (MA) is associated with microangiopathy (renal and retinal lesions) in insulin-dependent diabetic (IDDM) patients. In contrast MA does not reflect microvascular damage in a substantial number...

P. Fioretto, C. D. A. Stehouwer, M. Mauer, M. Chiesura-Corona, E. Brocco… in Diabetologia (1998)

Article

Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study

Microalbuminuria is a strong predictor of cardiovascular disease. The aim of this study was to investigate whether microalbuminuria is part of a cluster of risk factors, the insulin resistance syndrome (IRS),...

A. Jager, P. J. Kostense, G. Nijpels, R. J. Heine, L. M. Bouter… in Diabetologia (1998)

Article

Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose

In subjects with impaired glucose tolerance hyperproinsulinaemia has been shown to be predictive for progression to Type II (non-insulin-dependent) diabetes mellitus. These findings are often interpreted as e...

J. B. Ruige, J. M. Dekker, G. Nijpels, C. Popp-Snijders, C. D. A. Stehouwer… in Diabetologia (1999)

Article

Arterial compliance and distensibility are modulated by body composition in both men and women but by insulin sensitivity only in women

Large artery stiffening could contribute to the development of cardiovascular disease. The aim of this study was to investigate associations between arterial stiffness and diameter with insulin sensitivity an...

E. J. Giltay, J. Lambert, J. M. H. Elbers, L. J. G. Gooren, H. Asscheman… in Diabetologia (1999)

Article

Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation

Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease. C-reactive protein, its relation to a low degree of inflammatory activation an...

C. G. Schalkwijk, D. C. W. Poland, W. van Dijk, A. Kok, J. J. Emeis… in Diabetologia (1999)

Article

Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study

Aims/hypothesis. The degree of glycaemia has been shown to be associated with all-cause and cardiovascular mortality in diabetic subjects. Whether this association also exists in the general popu...

F. de Vegt, J. M. Dekker, H. G. Ruhé, C. D. A. Stehouwer, G. Nijpels… in Diabetologia (1999)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus

Aims/hypothesis. The sulphonylurea receptor is a subunit of the ATP-sensitive potassium channel in the pancreatic beta cell. Mutations at nt –3 of the splice acceptor site of exon 16 and a silent...

L. M. ’t Hart, J. M. Dekker, T. W. van Haeften, J. B. Ruige… in Diabetologia (2000)

Article

Glucose tolerance and other determinants of cardiovascular autonomic function: the Hoorn Study

Aims/hypothesis. Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of b...

J. Gerritsen, J. M. Dekker, B. J. TenVoorde, F. W. Bertelsmann… in Diabetologia (2000)

Article

A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism—The Hoorn Study

Type 2 diabetes is not only associated with hyperglycaemia, but also with disorders of lipid metabolism. The aim of this study was to investigate the association of triglyceride and non-HDL-cholesterol concent...

G. Bos, J. M. Dekker, G. Nijpels, F. de Vegt, M. Diamant… in Diabetologia (2003)

Article

Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers

Insulin possesses vasodilatory actions that may be important in regulating its access to insulin-sensitive tissues. Our study aims to directly measure changes in response to insulin in the human skeletal muscl...

R. T. de Jongh, A. D. H. Clark, R. G. IJzerman, E. H. Serné, G. de Vries… in Diabetologia (2004)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes.

R. M. van Dam, J. M. Dekker, G. Nijpels, C. D. A. Stehouwer, L. M. Bouter… in Diabetologia (2004)

Article

Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes—the EURODIAB Prospective Complications Study

The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular com...

M. T. Schram, N. Chaturvedi, C. G. Schalkwijk, J. H. Fuller… in Diabetologia (2005)