21 Result(s)

Article

Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease

Micro- and macrovascular complications are common among persons with type 2 diabetes. Recently there has been growing interest to investigate the potential of circulating small non-coding RNAs (sncRNAs) as con...

L. M. ’t Hart, J. A. de Klerk, G. A. Bouland, J. H. D. Peerlings, M. T. Blom… in Endocrine (2024)

Article

Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

We examined the effects of serum insulin levels on vagal control over the heart and tested the hypothesis that higher fasting insulin levels are associated with lower vagal control. We also examined whether ex...

M. Berkelaar, E. M. W. Eekhoff, A. M. C. Simonis-Bik, D. I. Boomsma… in Diabetologia (2013)

Article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...

A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… in Diabetologia (2013)

Article

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts

In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia mutated (ATM) gene in ...

N. van Leeuwen, G. Nijpels, M. L. Becker, H. Deshmukh, K. Zhou… in Diabetologia (2012)

Article

The heritability of beta cell function parameters in a mixed meal test design

We estimated the heritability of individual differences in beta cell function after a mixed meal test designed to assess a wide range of classical and model-derived beta cell function parameters.

A. M. C. Simonis-Bik, D. I. Boomsma, J. M. Dekker, M. Diamant… in Diabetologia (2011)

Article

Genetic association analysis of LARS2 with type 2 diabetes

LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). Howeve...

E. Reiling, B. Jafar-Mohammadi, E. van ’t Riet, M. N. Weedon… in Diabetologia (2010)

Article

Genetic influences on the insulin response of the beta cell to different secretagogues

The aim of the present study was to estimate the heritability of the beta cell insulin response to glucose and to glucose combined with glucagon-like peptide-1 (GLP-1) or with GLP-1 plus arginine.

A. M. C. Simonis-Bik, E. M. W. Eekhoff, M. H. M. de Moor, M. H. H. Kramer… in Diabetologia (2009)

Article

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

Variation in fasting plasma glucose (FPG) within the normal range is a known risk factor for the development of type 2 diabetes. Several reports have shown that genetic variation in the genes for glucokinase (GCK

E. Reiling, E. van ’t Riet, M. J. Groenewoud, L. M. C. Welschen… in Diabetologia (2009)

Article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

S. A. Schäfer, O. Tschritter, F. Machicao, C. Thamer, N. Stefan… in Diabetologia (2009)

Article

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemi...

M. J. Groenewoud, J. M. Dekker, A. Fritsche, E. Reiling, G. Nijpels… in Diabetologia (2008)

Article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

S. A. Schäfer, O. Tschritter, F. Machicao, C. Thamer, N. Stefan… in Diabetologia (2008)

Article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide...

S. A. Schäfer, O. Tschritter, F. Machicao, C. Thamer, N. Stefan… in Diabetologia (2007)

Article

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus

L. M. 't Hart, J. M. Dekker, R. J. Heine, Dr. J. A. Maassen in Diabetologia (2003)

Article

Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus

Aims/hypothesis. The sulphonylurea receptor is a subunit of the ATP-sensitive potassium channel in the pancreatic beta cell. Mutations at nt –3 of the splice acceptor site of exon 16 and a silent...

L. M. ’t Hart, J. M. Dekker, T. W. van Haeften, J. B. Ruige… in Diabetologia (2000)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)