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Article
Treatment with dapagliflozin increases FGF-21 gene expression and reduces triglycerides content in myocardial tissue of genetically obese mice
The association between obesity and some cardiovascular complications such as heart failure (HF) is well established, and drugs affecting adiposity are supposed to be promising treatments for these conditions....
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Article
The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007
Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD). The natural history of diabetic nephropathy has changed over the last decades, as a consequence of better metabolic and blood pr...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Heterogeneous nature of microalbuminuria in NIDDM: studies of endothelial function and renal structure
Microalbuminuria (MA) is associated with microangiopathy (renal and retinal lesions) in insulin-dependent diabetic (IDDM) patients. In contrast MA does not reflect microvascular damage in a substantial number...
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Article
Down-regulation of glomerular matrix metalloproteinase-2 gene in human NIDDM
Regulation of mesangial matrix deposition is a dynamic phenomenon involving synthetic and degradative processes. The latter involve a number of matrix metalloproteinases (MMP) and tissue inhibitors of matrix ...
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Article
Elevated sodium-lithium countertransport activity in erythrocytes is predictive of the development of microalbuminuria in IDDM
Pathogenetic mechanisms other than the quality of metabolic control may play a role in the development of diabetic nephropathy. Some cross-sectional studies have shown that elevated erythrocyte sodium-lithium...
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Article
Pathophysiology of diabetic complications
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Article
Growth factors and diabetic nephropathy: Kidney structure and therapeutic interventions
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Article
Patterns of renal injury in NIDDM patients with microalbuminuria
Microalbuminuria predicts overt nephropathy in non-insulin-dependent diabetic (NIDDM) patients; however, the structural basis for this functional abnormality is unknown. In this study we evaluated renal struc...
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Article
Indices of renal structure and function in patients with type 1 diabetes mellitus
The evaluation of renal biopsies from diabetic patients rests upon measurements of many structures in glomeruli, the tubules and the interstitium. These individual values can also be expressed as an index of r...
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Article
Impaired response to angiotensin II in Type 1 (insulin-dependent) diabetes mellitus. Role of prostaglandins and sodium-lithium countertransport activity
The pathogenesis of diabetic nephropathy remains elusive. A role for renal prostaglandins in antagonizing the hormonal effects of renin-angiotensin II has been postulated as a putative factor leading to hyperf...
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Article
Ketone bodies increase glomerular filtration rate in normal man and in patients with Type 1 (insulin-dependent) diabetes mellitus
The purpose of this study was to investigate whether the administration of acetoacetic and hydrochloric acids in a group of control and Type 1 (insulin-dependent) diabetic patients influenced renal haemodynami...
