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Article
Histopathological concordance between prostate biopsies and radical prostatectomy specimens—implications of transrectal and transperineal biopsy approaches
This study aimed to evaluate the histopathological concordance rates between prostate biopsies and radical prostatectomy specimens according to the applied biopsy approach (transrectal or transperineal).
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Article
Open AccessPlasma ESR1 mutations and outcome to first-line paclitaxel and bevacizumab in patients with advanced ER-positive/HER2-negative breast cancer
ESR1 mutations have been identified as mechanism for endocrine resistance and are also associated with a decreased overall survival. We assessed ESR1 mutations in circulating tumor DNA (ctDNA) for impact on outco...
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Chapter and Conference Paper
Development of a Hot Cutting Process for Functional Parts by Stress State-Dependent Damage Modeling
by forming is the method of choice for the production of complex components with functional surfaces. With increasing strength, this method is no longer applicable due to the high tool load and risk of produc...
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Article
Open AccessCardiotoxicity during long-term trastuzumab use in patients with HER2-positive metastatic breast cancer: who needs cardiac monitoring?
Patients with HER2-positive metastatic breast cancer (MBC) usually receive many years of trastuzumab treatment. It is unknown whether these patients require continuous left ventricular ejection fraction (LVEF)...
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Article
Hierarchical Modeling of Structural Coefficients for Heterogeneous Networks with an Application to Animal Production Systems
Understanding the interconnections between performance outcomes in a system is increasingly important for integrated management. Structural equation models (SEMs) are a type of multiple-variable modeling strat...
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Article
Open AccessIncreased tooth mobility after fixed orthodontic appliance treatment can be selectively utilized for case refinement via positioner therapy - a pilot study
Increased tooth mobility persists after fixed orthodontic appliance removal, which is therapeutically utilized for post-treatment finishing with positioners. As such a fine adjustment is only required for sele...
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Chapter and Conference Paper
Solution of trade-offs in the development of powertrains by use of online measurement technologies
In modern vehicle power trains for passenger cars combustion engines will be supplemented more and more by electric engines. However NOx- and particle emissions as well as CO2-emissions by fuel consumption are st...
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Article
Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading
Orthodontic treatment is based on the principle of force application to teeth and subsequently to the surrounding tissues and periodontal cells. Sequestosome 1 (SQSTM1) is a well-known marker for autophagy, wh...
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Article
Radiological complete remission in HER2-positive metastatic breast cancer patients: what to do with trastuzumab?
Patients with HER2-positive metastatic breast cancer (MBC) treated with trastuzumab may experience durable tumor response for many years. It is unknown if patients with durable radiological complete remission ...
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Article
Open AccessAggression in BALB/cJ mice is differentially predicted by the volumes of anterior and midcingulate cortex
Anterior cingulate cortex (ACC) and midcingulate cortex (MCC) have been implicated in the regulation of aggressive behaviour. For instance, patients with conduct disorder (CD) show increased levels of aggressi...
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Article
Potential impact of lingual retainers on oral health: comparison between conventional twistflex retainers and CAD/CAM fabricated nitinol retainers
To evaluate the impact of a novel computer-fabricated lingual nitinol retainer compared to a conventional lingual flexible spiral wire twistflex retainer on oral health.
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Article
Open AccessSelecting the optimal position of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer – the SONIA study: study protocol for a randomized controlled trial
Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth fa...
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Article
Damage-regulated autophagy modulator 1 in oral inflammation and infection
Damage-regulated autophagy modulator (DRAM) 1 is a p53 target gene with possible involvement in oral inflammation and infection. This study sought to examine the presence and regulation of DRAM1 in periodontal...
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Article
Measurement of Local Mechanical Properties of T91 Steel Corroded by Molten Lead-Bismuth Eutectic Alloy via Micropillar Compression Test
T91 ferritic/martensitic (F/M) steel is an expected structural material candidate for Gen IV liquid lead-bismuth cooled nuclear reactors. However, molten lead-bismuth eutectic alloy (mLBE) often causes liquid-...
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Article
In vivo determination of tooth mobility after fixed orthodontic appliance therapy with a novel intraoral measurement device
Valid measurement systems recording tooth mobility upon displacement within the subtle range of physiological strains are missing. Here, we introduce a novel in vivo measurement device and demonstrate a first ...
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Article
Post-treatment changes in permanent retention
While permanent retention is today the method of choice to stabilize orthodontic treatment outcomes, recent studies have increasingly reported posttreatment changes in tooth position during permanent retention...
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Article
Adjuvant systemic therapy in early breast cancer: impact of guideline changes and clinicopathological factors associated with nonadherence at a nation-wide level
Over recent years, adjuvant systemic treatment guidelines (AST) for early-stage breast cancer have changed considerably. We aimed to assess the impact of these guideline changes on the administration of AST in...
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Article
Regulation of p53 under hypoxic and inflammatory conditions in periodontium
Different studies suggest that inflammation as well as hypoxia leads to an increase of p53 protein levels. However, the implication of p53 during oral inflammatory processes is still unknown. The aim of this s...
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Article
Symmetric and asymmetric expansion of molars using a Burstone-type transpalatal arch
A transpalatal arch (TPA) directly connecting the maxillary first molars can be used in passive (for stabilization) and active (for molar or segment movement) modes. Activation may be symmetric or asymmetric. ...
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Article
Effect of growth factors on antimicrobial peptides and pro-inflammatory mediators during wound healing
Antimicrobial peptides (AMPs), such as human beta-defensin-2 (hBD-2) and the CC-chemokine ligand 20 (CCL20), exhibit direct microbicidal effects and mediator-like activity. It was hypothesized that wounding in...
