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Article
The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research
The All of Us Research Program has prioritized the enrollment of people from backgrounds that are historically under-represented in medical research to bring precision medicine to the full diversity of the US ...
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Article
Open AccessDiffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens
Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to r...
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Article
Open AccessSample size and power determination when limited preliminary information is available
We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...
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Article
Open AccessAssessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI)
Radiographic density adversely affects the performance of X-ray mammography and can be particularly problematic in younger and high-risk women. Because of this limitation, there is significant ongoing effort t...
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Article
Open AccessSpectral discrimination of breast pathologies in situusing spatial frequency domain imaging
Nationally, 25% to 50% of patients undergoing lumpectomy for local management of breast cancer require a secondary excision because of the persistence of residual tumor. Intraoperative assessment of specimen m...
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Article
Open AccessOptical imaging correlates with magnetic resonance imaging breast density and revealscomposition changes during neoadjuvant chemotherapy
In addition to being a risk factor for breast cancer, breast density has beenhypothesized to be a surrogate biomarker for predicting response toendocrine-based chemotherapies. The purpose of this study was to ...
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Article
Open AccessEFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment
There are conflicting reports regarding the function of EFEMP1 in different cancer types. In this study, we sought to evaluate the role of EFEMP1 in malignant glioma biology.
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Article
Open AccessSpatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer’s Disease
Extensive changes in neural tissue structure and function accompanying Alzheimer’s disease (AD) suggest that intrinsic signal optical imaging can provide new contrast mechanisms and insight for assessing AD ap...
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Article
Focusing light in scattering media
Combining ultrasonic modulation and optical phase conjugation allows light to be tightly focused in a scattering medium, providing benefits for studies of photophysical, photochemical and photobiological proce...
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Article
Open AccessPAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A
We reported that PAX6 suppresses glioblastoma cell growth in vivo and anchorage-independent growth without significant alteration of cell proliferation in vitro, suggesting that PAX6 may alter the tumor microe...
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Article
Imaging in breast cancer: Diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are non-invasive diagnostic techniques that employ near-infrared (NIR) light to quantitatively characterize the optical properties of centim...
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Article
Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids
During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investiga...
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Article
Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids
The response of human glioma spheroids to repetitive 5-aminolevulinic acid-mediated photodynamic therapy (PDT) was investigated. In all cases, light fluences were kept below toxic thresholds to simulate condit...
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Article
ALA- and ALA-ester-mediated Photodynamic Therapy of Human Glioma Spheroids
The effects of photodynamic therapy (PDT) in human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or ALA esters, are investigated. Spheroid survival and growth are monitored following PDT at repres...
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Chapter
Two-Photon Microscopy in Highly Scattering Tissue
Molecular excitation by two-photon absorption and the subsequent fluorescence have proved to be a useful tool for imaging biological systems using laser-scanning microscopy (Denk et al., 1990). In two-photon f...
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Article
Fluorescence resonance energy transfer: FRET studies of ligand binding to cell surface receptors
We describe a simple optical system employing fluorescence resonance energy transfer (FRET) to identify potential binding domains on the macrophage scavenger receptor for the ligand maleylated bovine serum alb...
