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Article
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
Liver metastasis (LM) confers poor survival and therapy resistance across cancer types, but the mechanisms of liver-metastatic organotropism remain unknown. Here, through in vivo CRISPR–Cas9 screens, we found ...
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Article
Open AccessNon-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis1–4, yet the extent to which this effect depends on the immune system remains unknown. Using ContactTracing—a newly developed, validated and benchmark...
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Article
Open AccessTumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression
The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) fostering c...
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Article
Open AccessLoss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating ge...
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Article
Open AccessCancer metastasis as a non-healing wound
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour cells are released from the primar...
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Article
Author Correction: L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Regenerative lineages and immune-mediated pruning in lung cancer metastasis
Developmental processes underlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment during tumor progression and under the selective pressures of immune surveillance...
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Article
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer
Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM+ cells in human colorectal...
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Article
Open AccessUrothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained unin...
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Article
Chromosomal instability drives metastasis through a cytosolic DNA response
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in me...
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Article
Numerical chromosomal instability mediates susceptibility to radiation treatment
The exquisite sensitivity of mitotic cancer cells to ionizing radiation (IR) underlies an important rationale for the widely used fractionated radiation therapy. However, the mechanism for this cell cycle-depe...
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Article
Open AccessSpectral discrimination of breast pathologies in situusing spatial frequency domain imaging
Nationally, 25% to 50% of patients undergoing lumpectomy for local management of breast cancer require a secondary excision because of the persistence of residual tumor. Intraoperative assessment of specimen m...
