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Article
Open AccessA missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome
Hoyeraal-Hreidarsson syndrome (HHS) is the most severe form of dyskeratosis congenita (DC) and is caused by mutations in genes involved in telomere maintenance. Here, we identified male siblings from a family ...
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Article
Open AccessHip, vertebral, and wrist fracture risks and schizophrenia: a nationwide longitudinal study
Fractures are a great health issue associated with morbidity, quality of life, life span, and health care expenditure. Fractures are correlated with cardiovascular disease, type 2 diabetes mellitus, cerebrovas...
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Article
Smart Traffic Offloading with Mobile Edge Computing for Disaster-Resilient Communication Networks
When a large-scale natural disaster happens, the evolved node B (eNB) of the disaster area (DA) may be destroyed, and the core network (CN) may be congested with massive data traffic. A disaster-resilient comm...
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Article
Open AccessThe type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway
The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...
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Article
Open AccessSample size and power determination when limited preliminary information is available
We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...
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Article
Open AccessCaffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats
Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protect...
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Article
Open AccessUtilizing Multiple in Silico Analyses to Identify Putative Causal SCN5A Variants in Brugada Syndrome
Brugada syndrome (BrS) is an inheritable sudden cardiac death disease mainly caused by SCN5A mutations. Traditional approaches can be costly and time-consuming if all candidate variants need to be validated throu...
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Article
Open AccessCaffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats
Glucose intolerance and cardiovascular complications are major symptoms in patients with diabetes. Many therapies have proven beneficial in treating diabetes in animals by protecting the cardiovascular system ...
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Article
Open AccessOptical imaging correlates with magnetic resonance imaging breast density and revealscomposition changes during neoadjuvant chemotherapy
In addition to being a risk factor for breast cancer, breast density has beenhypothesized to be a surrogate biomarker for predicting response toendocrine-based chemotherapies. The purpose of this study was to ...
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Article
Prazosin induces p53-mediated autophagic cell death in H9C2 cells
Prazosin, a quinazoline-based α1-adrenoceptor antagonist, is known to induce cell death, and this effect is independent of its α-blockade activity. However, the detailed molecular mechanisms involved are still no...
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Article
DPP4 deficiency preserves cardiac function via GLP-1 signaling in rats subjected to myocardial ischemia/reperfusion
Dipeptidyl peptidase-4 (DPP4) enzyme inhibition has been reported to increase plasma glucagon-like peptide-1 (GLP-1) level for controlling postprandial glucose concentration. Both DPP4 inhibitors and GLP-1 ana...
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Article
Thaliporphine ameliorates cardiac depression in endotoxemic rats through attenuating TLR4 signaling in the downstream of TAK-1 phosphorylation and NF-κB signaling
Thaliporphine was found to ameliorate endotoxin-induced circulatory failure and mortality in rodents. The aims of the present study were to assess whether thaliporphine could improve cardiac function in endoto...
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Article
GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats
Glucagon-like peptide-1 (GLP-1) is rapidly cleaved by widely expressed dipeptidyl peptidase-4 (DPP4) enzyme. Both DPP4 inhibitors and GLP-1 analogue are being developed as a novel class of oral antihyperglycem...
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Article
Transforming growth factor-β type I receptor/ALK5 contributes to doxazosin-induced apoptosis in H9C2 cells
The mechanism of doxazosin-induced apoptosis through α1-adrenoceptor-independent pathway has been reported in various types of cell models. However, the molecular events involved in this effect are still not full...
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Article
Open AccessDistinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutations
The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The mol...
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Article
Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin
In Langendorff-perfused adult rat heart with constant pressure at 80 mmHg, we found doxazosin, an α1 adrenoceptor blocker, at 10 μM prolonged PR interval and induced occasional arrhythmia followed by complete inh...
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Article
Does the concordance between medical records and patient self-report vary with patient characteristics?
Few studies of the concordance between patient self-report and medical record data have examined how concordance varies with patient characteristics, and results of such studies have been mixed. Given discrepa...
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Article
Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes
Petasites formosanus, an indigenous species of Petasites, has been used to treat cardiovascular diseases such as hypertension for years. We have suggested recently that S-petasin, a major...
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Article
Comparison of the electromechanical responsiveness of alpha-1-adrenoceptor stimulation in ventricles of normal and cardiomyopathic hamsters
Alterations in α1-adrenoceptor (α1AR) density and related signal transduction proteins were reported in cardiomyopathic hearts in the failing stage. The electrome-chanical modification of α1-adrenergic stimulatio...
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Article
Role of protein kinase C in mediating alpha-1-adrenoceptor-induced negative inotropic response in rat ventricles
The aim of this study was to determine the effect of protein kinase C (PKC) activation on intracellular Ca2+ transient and its relation to α1-adrenoceptor (α1-AR)-stimulated negative inotropic response in rat ven...
