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Article
Open AccessThe adrenal steroid profile in adolescent depression: a valuable bio-readout?
There is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are l...
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Chapter
Störungen der Geschlechtsreife
Die Pubertät als Übergangsphase zwischen Kindheit und Erwachsenenalter ist der Lebensabschnitt, in dem sich die sekundären Geschlechtsmerkmale bis zur kompletten Ausprägung des adulten weiblichen oder männlich...
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Chapter
Hypothalamus und Hypophyse: Anatomie, Physiologie und Erkrankungen
Der Hypothalamus ist evolutionsgeschichtlich eine der ältesten Hirnregionen der Säugetiere. Er ist die übergeordnete Steuerungseinheit, die Informationen aus der Umwelt (Licht, Wärme, Schmerz, Geruch etc.), In...
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Article
Open AccessMortality in children with classic congenital adrenal hyperplasia and 21-hydroxylase deficiency (CAH) in Germany
Adrenal crises in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) are life-threatening and have the potential to death.
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Living Reference Work Entry In depth
Hypothalamus und Hypophyse: Anatomie, Physiologie und Erkrankungen
Der Hypothalamus ist evolutionsgeschichtlich eine der ältesten Hirnregionen der Säugetiere. Er ist die übergeordnete Steuerungseinheit, die Informationen aus der Umwelt (Licht, Wärme, Schmerz, Geruch etc.), In...
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Living Reference Work Entry In depth
Störungen der Geschlechtsreife
Die Pubertät als Übergangsphase zwischen Kindheit und Erwachsenenalter ist der Lebensabschnitt, in dem sich die sekundären Geschlechtsmerkmale bis zur kompletten Ausprägung des adulten weiblichen oder männlich...
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Article
Obesity in patients with Bardet–Biedl syndrome: influence of appetite-regulating hormones
Bardet-Biedl syndrome (BBS) is a genetic disorder with obesity as one of the major phenotypic criterion, which is proposed to be of neuroendocrine origin. Therefore, disturbances in appetite-regulating hormone...
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Article
Alterations in appetite-regulating hormones influence protein–energy wasting in pediatric patients with chronic kidney disease
Protein–energy wasting is a common problem in pediatric patients with chronic kidney disease (CKD). Disturbances in appetite-regulating hormones have been suggested as causative factors. Acyl ghrelin is a pote...
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Article
Open AccessDoes the cortisol response to stress mediate the link between expressed emotion and oppositional behavior in Attention-Deficit/Hyperactivity-Disorder (ADHD)?
Expressed Emotions (EE) are associated with oppositional behavior (OPB) in children with Attention Deficit/Hyperactivity Disorder (ADHD). EE has been linked to altered stress responses in some disorders, but A...
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Article
Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas
Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a...
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Article
Short stature in children with an apparently normal male phenotype can be caused by 45,X/46,XY mosaicism and is susceptible to growth hormone treatment
Girls with unexplained short stature are routinely screened for the presence of Ullrich-Turner syndrome by clinical examination, laboratory tests, and karyoty**. In this study, we performed chromosomal analy...
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Article
Venous sampling can be crucial in identifying the testicular origin of idiopathic male luteinising hormone-independent sexual precocity
It has been recently shown that male LH-independent sexual precocity is caused by a somatic activating mutation in the luteinising hormone receptor (LHR) of Leydig cell tumours. In each of the patients descri...
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Article
Hormone Ontogeny in the Ovine Fetus: XIX: The Effect of a Potent Luteinizing Hormone-Releasing Factor Agonist on Gonadotropin and Testosterone Release in the Fetus and Neonate'
ABSTRACT: To investigate further the role of the hypothalamic luteinizing hormone releasing factor (LRF) pulse generator and the pituitary LRF receptor in the regulation of gonadotropin secretion and gonadal s...
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Chapter
Studies with Growth Hormone-Releasing Factor (GRF) in the Human
In 1982 Guillemin et al. (1) isolated, characterized, and synthesized an amidated, 44-amino-acid growth hormone-releasing factor (GRF44) from the pancreatic tumor of a patient with acromegaly. GRF44
