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Article
Impact of the introduction of EUCAST’s concept of “area of technical uncertainty”
On the first of January 2019, the European Committee on Antimicrobial Susceptibility Testing, EUCAST, introduced the concept of “area of technical uncertainty” (ATU). The aim was to report on the incidence of ...
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Article
Open AccessNef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV
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Article
Efficient gene transfer in CLL by mRNA electroporation
Chronic lymphocytic leukemia (CLL) consists of at least two major prognostic subgroups, characterized by different cellular and molecular markers. This observation sparked studies on the function and clinical ...
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Article
Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique
Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRβ) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute...
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Article
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
Chromosomal translocations with breakpoints in T-cell receptor (TCR) genes are recurrent in T-cell malignancies. These translocations involve the TCRαδ gene (14q11), the TCRβ gene (7q34) and to a lesser extent th...
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Article
Efficiency of transgenic T cell generation from gene-marked cultured human CD34+ cord blood cells is determined by their maturity and the cytokines present in the culture medium
Success of gene therapy for diseases affecting the T cell lineage depends on the thymic repopulation by genetically engineered hematopoietic progenitor cells (HPC). Although it has been shown that retrovirally...
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Article
Arrest of MCF-7 cell migration by lamininin vitro: possible mechanisms
Laminin, a major basement membrane component, arrested the migration of MCF-7/AZ human breast adenocarcinoma cells that were not invasivein vitro. Migration of invasive MCF-7/6 cells was not affected by laminin. ...
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Article
Effects of serotonin and ketanserin on the functional morphology of chick down feather bulbi in vitro
Chick feather bulbi cultured in vitro showed an increased DNA synthesis and a delayed keratinization after treatment with ketanserin, a serotonin2 antagonist with wound-healing properties. In contrast, serotonin ...
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Article
In vitro culture of chick down feather bulbi: A tool to obtain proliferating and differentiating keratinocytes in an organotypic structure
Chick down feather bulbi can be cultured in different culture systems. Morphological analysis and3H-thymidine incorporation measurements prove that the majority of cells are viable epithelial cells.