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Article
RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation
Myeloproliferative neoplasms are frequently associated with aberrant constitutive tyrosine kinase (TK) activity resulting from chimaeric fusion genes or point mutations such as BCR-ABL1 or JAK2 V617F. We report h...
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Article
Interest of the association azacitidine–lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype
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Article
Extensive mutational status of genes and clinical outcome in pediatric acute myeloid leukemia
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Article
Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases
The t(8;16)(p11;p13) is a rare translocation involved in de novo and therapy-related myelomonocytic and monocytic acute leukemia. It fuses two genes encoding histone acetyltransferases (HATs), MYST3 located at 8p...
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Article
Severe neurological crisis in a patient with hereditary tyrosinaemia type I after interruption of NTBC treatment
Neurological crises do not occur in patients with tyrosinaemia type I treated with NTBC. We report an 8 month-old boy with severe neurological crisis after interruption of NTBC treatment including progressive ...
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Article
NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia
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Article
Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH)
A series of 38 patients with acute myeloblastic leukemia (AML) with 49 or more chromosomes and without structural abnormalities was selected within the Groupe Francophone de Cytogénétique Hématologique (GFCH) ...
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Article
Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique
Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRβ) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute...
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Article
NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique
The NUP98 gene is fused with 19 different partner genes in various human hematopoietic malignancies. In order to gain additional clinico-hematological data and to identify new partners of NUP98, the Groupe Franco...
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Article
A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma
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Article
PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation
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Article
t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)
To accurately estimate the incidence of HOX11L2 expression, and determine the associated cytogenetic features, in T-cell acute lymphoblastic leukemia (T-ALL), the Groupe Français de Cytogénétique Hématologique...
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Article
A novel real-time RT-PCR assay for quantification of OTT-MAL fusion transcript reliable for diagnosis of t(1;22) and minimal residual disease (MRD) detection
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Article
Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group
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Article
Effects of stretch-shortening cycle training on mechanical properties and fibre type transition in the rat soleus muscle
The effects of exercise training on mechanical properties and fibre type transitions have been investigated in rat soleus muscle. The exercise was a repetition of stretch-shortening cycles. A method of dual co...
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Article
Quantification of T- and H-responses before and after a period of endurance training
Tendon (T-) and Hoffmann (H-) responses in the soleus muscle were quantified either separately or in association to compare the mononeurons activated and to study their changes after a period of endurance trai...
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Article
Stiffness changes and fibre type transitions in rat soleus muscle produced by jum** training
Rat soleus muscles were overloaded with intent to induce a relative increase in fast fibres and modifications in muscular stiffness. The overloading technique was a training period consisting of an 11-week ver...
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Article
Effect of antagonistic contractions on the reflex response of a bifunctional muscle
With reference to the concept that contraction of a muscle can be inhibited by contraction of its antagonists, the excitability of a bifunctional muscle, the soleus (plantarflexor and adductor) was studied dur...
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Article
Synergy between bifunctional muscles at the ankle joint
The activation of antagonistic muscles is studied during isometric combined contractions of bifunctional muscles. It is established that the co-contraction mechanism observed in such situations limits unwanted...
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Article
Contribution des muscles biceps brachii et pronator teres à l'effort de prono-supination
The electrical activity of the biceps brachii and pronator teres muscles is studied through the prono-supination of the forearm in some anisometrical conditions (dynamic work) when the inertia of the mobile sy...
