35 Result(s)

Article

Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

Minimal residual disease (MRD) is a powerful prognostic factor in acute lymphoblastic leukemia (ALL) and is used for patient stratification and treatment decisions, but its precise role in Philadelphia chromos...

H. Pfeifer, G. Cazzaniga, V. H. J. van der Velden, J. M. Cayuela, B. Schäfer… in Leukemia (2019)

Article

Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials

C Piette, S Suciu, E Clappier, Y Bertrand, S Drunat, S Girard, K Yakouben… in Leukemia (2018)

Article

IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951

The added value of IKZF1 gene deletion (IKZF1^del) as a stratifying criterion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We performed a comprehensive analysis of the impact of IKZ...

E Clappier, N Grardel, M Bakkus, J Rapion, B De Moerloose, P Kastner, A Caye… in Leukemia (2015)

Article

Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia

T Lana, P de Lorenzo, S Bresolin, I Bronzini, M L den Boer, H Cavé, E Froňková… in Leukemia (2015)

Article

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions

Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are used for risk stratification. However, a significant number of BCP-ALL patients are still genetically unassigned. Usi...

E Clappier, M-F Auclerc, J Rapion, M Bakkus, A Caye, A Khemiri, C Giroux… in Leukemia (2014)

Article

In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia

M Strullu, A Caye, B Cassinat, O Fenneteau, F Touzot, T Blauwblomme… in Leukemia (2013)

Article

Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL

Minimal residual disease (MRD) quantification is widely used for therapeutic stratification in pediatric acute lymphoblastic leukemia (ALL). A robust, reproducible, sensitivity of at least 0.01% has been achie...

R Garand, K Beldjord, H Cavé, C Fossat, I Arnoux, V Asnafi, Y Bertrand… in Leukemia (2013)

Article

The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation

Hematopoietic stem cell transplantation is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for diagnostic assays permit...

T Lion, F Watzinger, S Preuner, H Kreyenberg, M Tilanus, R de Weger, J van Loon… in Leukemia (2012)

Article

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We investigated the prognostic implication of hyperactivation ...

E Clappier, S Collette, N Grardel, S Girard, L Suarez, G Brunie, S Kaltenbach… in Leukemia (2010)

Article

A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia

E Chapiro, L J Russell, S Struski, H Cavé, I Radford-Weiss, V D Valle… in Leukemia (2010)

Article

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

E Chapiro, L Russell, E Lainey, S Kaltenbach, C Ragu, V Della-Valle, K Hanssens… in Leukemia (2010)

Article

Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008

Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value fo...

M Brüggemann, A Schrauder, T Raff, H Pfeifer, M Dworzak, O G Ottmann, V Asnafi… in Leukemia (2010)

Article

Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies

A Renneville, S Kaltenbach, E Clappier, S Collette, J-B Micol, B Nelken… in Leukemia (2010)

Article

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

Adult and child B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) differ in terms of incidence and prognosis. These disparities are mainly due to the molecular abnormalities associated with these two cl...

J Familiades, M Bousquet, M Lafage-Pochitaloff, M-C Béné, K Beldjord, J De Vos… in Leukemia (2009)