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Article
Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction
Adolescents with elevated body mass index (BMI) are at an increased risk for depression and body dissatisfaction. Type 2 diabetes (T2D) is an established risk factor for depression. However, shared genetic ris...
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Article
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has t...
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Article
Psychosis superspectrum I: Nosology, etiology, and lifespan development
This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis superspectrum was developed to address sh...
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Article
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach
Bipolar disorder (BD) and schizophrenia (SZ) are associated with higher odds of suicide attempt (SA). In this study, we aimed to explore the effect of BD and SZ genetic liabilities on SA, also considering the ...
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Article
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset and progression and have potential to produce clinically useful biomarkers. A growing body of GWAS focuses on quantitative ...
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Article
Open AccessWhole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes
Recent large-scale genome-wide association studies (GWAS) have started to identify potential genetic risk loci associated with risk of suicide; however, a large portion of suicide-associated genetic factors af...
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Article
Open AccessGenome-wide association study meta-analysis of suicide death and suicidal behavior
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah an...
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Article
Open AccessGenetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the...
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Article
Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function
Major depressive disorder (MDD) and opioid use disorder (OUD) are common, potentially fatal, polygenic disorders that are moderately heritable and often co-occur. We examined the unique and shared associations...
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Article
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within a large, multi-ancestry coh...
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Article
The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders
Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders is not well studied. We in...
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Article
Open AccessAssessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach
Bipolar disorder (BP) suicide death rates are 10–30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, ...
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Article
Brief Report: Genetic Links Between Autism and Suicidal Behavior—A Preliminary Investigation
Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased ...
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Article
International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most se...
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Article
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...
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Article
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and charact...
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Article
Opportunities for an enhanced integration of neuroscience and genomics
Neuroimaging and genetics are two rapidly expanding fields of research. Thoughtful integration of these areas is critical for ongoing large-scale research into the genetic mechanisms underlying brain structure...
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Article
Cross-Disorder Psychiatric Genomics
The following review provides some description of the movement in cross-disorder psychiatric genomics toward addressing both comorbidity and polygenicity.
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Article
Comparison of Twin and Extended Pedigree Designs for Obtaining Heritability Estimates
This study explores power assumptions relating to extended pedigree designs (EPD) and classical twin designs (CTD). We conducted statistical analyses to compare the power of the two designs for examining neuro...
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Chapter
Anhedonia as an Indicator of Genetic Vulnerability to Schizophrenia
The symptom of anhedonia has been central to causal theories of schizophrenia put forth by Rado and Meehl. Yet, the significance of anhedonia to the etiology of schizophrenia remains unclear. Anhedonia is rega...
