-
Article
The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders
Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders is not well studied. We in...
-
Article
Open AccessWhole exome sequencing in Alopecia Areata identifies rare variants in KRT82
Alopecia areata is a complex genetic disease that results in hair loss due to the autoimmune-mediated attack of the hair follicle. We previously defined a role for both rare and common variants in our earlier ...
-
Article
Open AccessPublisher Correction: TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessTCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes
The association between several Single Nucleotide Polymorphisms (SNPs) within the transcription factor 7-like 2 (TCF7L2) gene and Type 2 Diabetes (T2D) as well as additional T2D-related traits is well established...
-
Article
Noncoding deletions reveal a gene that is critical for intestinal function
Large-scale genome sequencing is poised to provide a substantial increase in the rate of discovery of disease-associated mutations, but the functional interpretation of such mutations remains challenging. Here...
-
Article
Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). However, the role of its downstream signaling molecule, the low-density lipopr...
-
Article
Open AccessThe human olfactory transcriptome
Olfaction is a versatile sensory mechanism for detecting thousands of volatile odorants. Although molecular basis of odorant signaling is relatively well understood considerable gaps remain in the complete cha...
-
Article
Open AccessVarElect: the phenotype-based variation prioritizer of the GeneCards Suite
Next generation sequencing (NGS) provides a key technology for deciphering the genetic underpinnings of human diseases. Typical NGS analyses of a patient depict tens of thousands non-reference coding variants,...
-
Article
Erratum to: Association of the ZFPM2 gene with antipsychotic-induced parkinsonism in schizophrenia patients
-
Article
Association of the ZFPM2 gene with antipsychotic-induced parkinsonism in schizophrenia patients
Antipsychotic-induced parkinsonism (AIP) is a severe adverse affect of antipsychotic drug treatment. Recently, our group performed a genome-wide association study (GWAS) for AIP severity, and identified severa...
