-
Article
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach
Bipolar disorder (BD) and schizophrenia (SZ) are associated with higher odds of suicide attempt (SA). In this study, we aimed to explore the effect of BD and SZ genetic liabilities on SA, also considering the ...
-
Article
Open AccessBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of b...
-
Article
Open AccessPrenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans
The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DN...
-
Article
Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial dysfunction can modulate ...
-
Article
Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics
Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as modifications of DNA methylation, histone deacetylation, an...
-
Article
Accelerated epigenetic aging in older adults with HIV disease: associations with serostatus, HIV clinical factors, and health literacy
The prevalence of older persons with HIV (PWH) disease has increased considerably in the last 20 years, but our understanding of biological factors of aging and their clinical correlates among PWH remains limi...
-
Article
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder
Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are greatly elevated in BD and are associated with dec...
-
Article
Epigenetic aging in psychiatry: clinical implications and therapeutic opportunities
-
Chapter
Genetic Biomarkers of Psychiatric Disorders
Psychiatric disorders are multifactorial conditions known to have a significant genetic component, as seen in family, twin, and adoption studies. After decades of linkage and candidate gene studies, technologi...
-
Article
Open AccessMolecular pathways of major depressive disorder converge on the synapse
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathw...
-
Article
Angiogenic gene networks are dysregulated in opioid use disorder: evidence from multi-omics and imaging of postmortem human brain
Opioid use disorder (OUD) is a public health crisis in the U.S. that causes over 50 thousand deaths annually due to overdose. Using next-generation RNA sequencing and proteomics techniques, we identified 394 d...
-
Article
Open AccessEssential genes from genome-wide screenings as a resource for neuropsychiatric disorders gene discovery
Genome-wide screenings of “essential genes”, i.e., genes required for an organism or cell survival, have been traditionally conducted in vitro in cancer cell lines, limiting the translation of results to other...
-
Article
Open AccessWhite matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis
White matter (WM) abnormalities in patients with cocaine use disorder (CUD) have been studied; however, the reported effects on the human brain are heterogenous and most results have been obtained from male pa...
-
Article
Open AccessTelomere length and epigenetic age acceleration in adolescents with anxiety disorders
Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study ...
-
Article
Open AccessConvergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients
Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models of psychiatric disorders that account for a patient’s genetic background. Here, we conducted an RNA-sequencing...
-
Chapter
Hypothalamus-Pituitary-Adrenal Axis Programming by Early-Life Stress: A Role Played by Inflammatory and Epigenetic Mechanisms
Early-life stress exposure, regardless whether pre-, peri-, or post-natal, has been shown to increase the risk for psychiatric disorders in vulnerable subjects. One of the hypothesis that explains this associa...
-
Article
TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation
Bipolar disorder (BD) is a chronic, debilitating illness with a global prevalence of up to 4.8%. The importance of understanding how dysfunctional mitochondria and mitophagy contribute to cell survival and dea...
-
Article
Are lithium effects dependent on genetic/epigenetic architecture?
-
Chapter
MicroRNAs in Major Depressive Disorder
Major depressive disorder (MDD) is a severe and chronic psychiatric disorder with a high prevalence in the population. Although our understanding of its pathophysiological mechanisms has significantly increase...
-
Chapter
The Methylome of Bipolar Disorder: Evidence from Human and Animal Studies
Bipolar disorder is a chronic and often severe psychiatric disorder with a complex multifactorial heritability. While it is known that the pathophysiology of bipolar disorder involves the interaction of severa...
