12 Result(s)
within
Brenda Cabrera-Mendoza
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Article
The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits
To investigate assortative mating (AM), participation bias and socioeconomic status (SES) with respect to the genetics of behavioural and psychiatric traits, we estimated AM signatures using gametic phase dise...
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Article
Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
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Article
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
GrimAge acceleration has previously predicted age-related morbidities and mortality. In the current study, we sought to examine how GrimAge is associated with genetic predisposition for systemic inflammation a...
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Article
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach
Bipolar disorder (BD) and schizophrenia (SZ) are associated with higher odds of suicide attempt (SA). In this study, we aimed to explore the effect of BD and SZ genetic liabilities on SA, also considering the ...
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Article
Open AccessBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of b...
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Article
Open AccessModeling the longitudinal changes of ancestry diversity in the Million Veteran Program
The Million Veteran Program (MVP) participants represent 100 years of US history, including significant social and demographic changes over time. Our study assessed two aspects of the MVP: (i) longitudinal cha...
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Article
Open AccessSex differences in the polygenic architecture of hearing problems in adults
Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predispo...
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Reference Work Entry In depth
Linking Behavior and Genetics: Psychopathology and Recognition of Anger and Other Emotions
Emotion recognition, particularly of anger expressions, has a crucial adaptive and social value for human beings. Similar to other human traits, emotion recognition is highly variable among individuals and has...
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Article
Open AccessDenisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introg...
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Article
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
UK Biobank (UKB) is a key contributor in mental health genome-wide association studies (GWAS) but only ~31% of participants completed the Mental Health Questionnaire (“MHQ responders”). We predicted generalize...
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Article
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may arise in response to severe traumatic event and is diagnosed based on three main symptom clusters (reexperiencing, avoidance, and hyperar...
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Living Reference Work Entry In depth
Linking Behavior and Genetics: Psychopathology and Recognition of Anger and Other Emotions
Emotion recognition, particularly of anger expressions, has a crucial adaptive and social value for human beings. Similar to other human traits, emotion recognition is highly variable among individuals and has...
