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Open AccessBrain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase
Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution1,2. In particular, brain insulin action increases whole-body insulin sensitivity, but these studies we...
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Article
Open AccessAcute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention
Exercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue (SCAT) might also contribute to the ...
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Article
Open AccessSex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight
Central insulin action influences cognitive processes, peripheral metabolism, and eating behavior. However, the contribution of obesity and sex on central insulin-mediated neural food cue processing still rema...
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Open AccessAuthor Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
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Article
Open AccessFree fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
The selection of carbohydrates or fat to generate intracellular energy is thought to be crucial for long-term metabolic health. While most studies assess fuel selection after a metabolic challenge, the determi...
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Article
Open AccessBody composition in term offspring after maternal gestational diabetes does not predict postnatal hypoglycemia
Offspring of mothers with gestational diabetes mellitus (GDM) have an increased risk of neonatal complications like birth trauma due to macrosomia or postnatal hypoglycemia, as well as long-term metabolic sequ...
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Article
Open AccessNo modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relat...
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Langzeiteffekte von Diabetespräventionsmaßnahmen
Diabetesprävention kann durch Lebensstilintervention, Pharmakotherapie oder eine Kombination aus beiden erreicht werden. In einer Vielzahl von wegweisenden randomisierten, kontrollierten Studien wurde festgest...
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Open AccessMaternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics of GDM, we studied miRNA profiles of maternal and fetal whole blood cells (WBCs) f...
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Non-alcoholic fatty liver disease and impaired proinsulin conversion as newly identified predictors of the long-term non-response to a lifestyle intervention for diabetes prevention: results from the TULIP study
Lifestyle intervention is effective to prevent type 2 diabetes. However, a considerable long-term non-response occurs to a standard lifestyle intervention. We investigated which risk phenotypes at baseline and...
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Open AccessExcessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies
Variation in FTO is the most important common genetic determinant of body weight. Altered energy metabolism could underlie this association. We hypothesized that higher circulating glucose or triglycerides can am...
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Erratum to: A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation
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A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation
Insulin resistance underlies the etiology of both type 2 diabetes and gestational diabetes. In pregnancy, insulin resistance is also associated with an unfavorable metabolic programming of the fetus, potential...
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Article
Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity
Fetal programming plays an important role in the pathogenesis of type 2 diabetes. The aim of the present study was to investigate whether maternal metabolic changes during OGTT influence fetal brain activity.
