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Article
Reirradiation on spine metastases: an Italian survey on behalf of palliative care and reirradiation study groups of Italian association of radiotherapy and clinical oncology (AIRO)
This survey derived from the collaboration between the Palliative Care and Reirradiation Study Groups of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Its aim was to obtain a real “snap...
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Article
Open AccessShort course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project)
Previous trials showed the tolerability and efficacy of a palliative radiotherapy (RT) regimen (SHARON) based on the 4 fractions delivered in 2 days in different oncological settings. In order to identify poss...
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Article
Open AccessStereotactic radiotherapy of nodal oligometastases from prostate cancer: a prisma-compliant systematic review
Androgen deprivation therapy (ADT) is the standard treatment of metastatic prostate cancer (PCa). However, metastases-directed therapies can delay the initiation or switch of systemic treatments and allow loca...
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Article
Open AccessIrradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases. Understanding the mechanisms ...
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Article
Open AccessThe role of radiotherapy in adult soft tissues sarcoma of the extremities
Local management of adult soft tissue sarcoma of the extremities has evolved over the past decades. Until the 1970s, radical surgery (amputations) was the standard therapeutic procedure resulting in significan...
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Article
Open AccessCorrection to: The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
A Correction to this paper has been published: https://doi.org/10.1038/s41419-021-03483-4
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Article
Open AccessTP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer
Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect...
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Article
Electrochemotherapy of skin metastases from breast cancer: a systematic review
Skin metastases occur in 5–30% of breast cancer (BC) patients. Standard treatments include systemic therapies (chemotherapy, endocrine therapy, and immunotherapy) and local treatments (surgery and radiotherapy...
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Article
Systematic review of stereotactic body radiotherapy for nodal metastases
The aim of this analysis was to assess the efficacy of stereotactic body radiotherapy (SBRT) in terms of local control (LC) and progression-free survival (PFS) in patients with lymph node metastases (NMs) from...
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Article
Open AccessThe androgen receptor/filamin A complex as a target in prostate cancer microenvironment
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to ...
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Article
Open AccessModeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental components contribute to the development, progression, and metastasization of disease, representing major hurdles in the identif...
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Article
Radiotherapy in palliation of thoracic tumors: a phase I–II study (SHARON project)
The main clinical goal for patients with advanced or metastatic thoracic cancer is palliation of tumor-related symptoms and improvement of quality of life. The aim of this phase I–II trial was to define the ma...
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Article
Efficacy and safety of 3D-conformal half body irradiation in patients with multiple bone metastases
Half-body irradiation (HBI) represented a standard treatment for multiple painful bone metastases (BMs). However, its use has progressively reduced due to the associated toxicity rates. The aim of this paper w...
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Article
Open Access3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little ...
