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Article
Open AccessFilamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen recep...
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Article
Open AccessRIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year s...
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Article
Open AccessThe nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue
Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in men worldwide. Its development and progression occur in concert with alterations in the surrounding tumor microenvironmen...
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Article
Open AccessTargeting ERβ to fight melanoma: a new valid approach?
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Article
Open AccessTherapeutic potential of TRPM8 antagonists in prostate cancer
Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear. Here, we have characterized and investigated the effects of...
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Article
Open AccessCommunication between cells: exosomes as a delivery system in prostate cancer
Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low ri...
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Article
Open AccessCorrection to: The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
A Correction to this paper has been published: https://doi.org/10.1038/s41419-021-03483-4
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Article
Open AccessThe androgen receptor/filamin A complex as a target in prostate cancer microenvironment
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to ...
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Article
Open AccessROS in cancer therapy: the bright side of the moon
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required f...
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Article
Open AccessAndrogens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly
Breast cancer (BC) is still characterized by high morbidity and mortality. A specific BC subtype named triple negative BC (TNBC) lacks estrogen and progesterone receptors (ER and PR, respectively) and is chara...
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Article
Open AccessCross-talk between androgen receptor and nerve growth factor receptor in prostate cancer cells: implications for a new therapeutic approach
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Protocol
Analysis of the Androgen Receptor/Filamin A Complex in Stromal Cells
The androgen receptor (AR), a ligand-regulated nuclear transcription factor, mediates differentiation and proliferation of target tissues. Its action is frequently associated with human proliferative diseases,...
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Non-genomic Action of Steroid Hormones: More Questions than Answers
In this chapter we aim to draw the attention of potential readers to several aspects of our research on non-genomic action of sex steroid hormones that have not as yet been fully investigated and might offer i...
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Article
Steroid signaling activation and intracellular localization of sex steroid receptors
In addition to stimulating gene transcription, sex steroids trigger rapid, non-genomic responses in the extra-nuclear compartment of target cells. These events take place within seconds or minutes after hormon...
