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Open AccessRIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year s...
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Open AccessExploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated ...
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Open AccessCorrection to: The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
A Correction to this paper has been published: https://doi.org/10.1038/s41419-021-03483-4
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Open AccessThe androgen receptor/filamin A complex as a target in prostate cancer microenvironment
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to ...
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Open AccessDual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement
Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer. Survival is poor and improved treatment options are urgently needed. Dual specificity phosphatase-6 (DUSP6) is actively involv...
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Open AccessROS in cancer therapy: the bright side of the moon
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required f...
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Obesity and Cancer: Linked Molecular Mechanisms
Obesity is related to metabolic defects that may promote not only cancer initiation, but also its progression. The molecular basis for the association between obesity and cancer is not fully understood; howeve...
