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Article
Open AccessSEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma
Despite the promise of dual BRAF/MEK inhibition as a therapy for BRAF-mutant (BRAF-mut) melanoma, heterogeneous responses have been observed in patients, thus predictors of benefit from therapy are needed. We ...
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Article
Open AccessValidation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medi...
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Article
Open AccessTP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer
Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect...
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Article
Open AccessApproaching the challenges of MKK3/p38delta MAPK targeting for therapeutic purpose in colorectal cancer
MKK3 is a member of the dual specificity kinase group specific upstream activator of p38 MAPK proteins. We originally identified MKK3 as mutant p53 (mutp53) gain-of-function (GOF) upregulated target gene in di...
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Article
Open AccessMKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide and understanding its underlying molecular mechanisms is crucial for the development of therapeutic strategies. The mitogen-activate...
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Article
Open AccessVery low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells
The possibility to combine Low Intensity UltraSound (LIUS) and Nanoparticles (NP) could represent a promising strategy for drugs delivery in tumors difficult to treat overcoming resistance to therapies. On one...
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Article
Open AccessThe beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells
Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding...
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Article
Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy
The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological function...
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Article
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras
32D cells expressing v-Ha-Ras fail to show a transformed phenotype. Since Ras requires an active IGF-1R for transformation of fibroblasts, we asked whether expression of IRS-1 or Shc (two of the major substrat...
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Article
Development of a murine orthotopic model of leukemia: Evaluation of TP53 gene therapy efficacy
The onco-suppressor gene TP53 has potential use in the gene therapy of many human cancers including leukemias. The latter indication derived from numerous experimental reports of p53-mediated suppressing effects ...
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Article
The role of wild-type p53 in the differentiation of primary hemopoietic and muscle cells
Experiments previously performed on 32D and C2C12 cell lines indicated that wild type p53 (wtp53) protein has a role in granulocyte and myotube differentiation. Since these are immortal cells, we asked whether...
