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  1. No Access

    Article

    The nuclear translocation of ERK1/2 as an anticancer target

    A hallmark of the ERK1/2 functioning is their nuclear translocation, which is mainly required for the induction of proliferation. Activated ERK1/2 molecules that remain in the cytoplasm initiate other activiti...

    Alexander Plotnikov, Karen Flores, Galia Maik-Rachline… in Nature Communications (2015)

  2. Article

    Open Access

    High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    microRNAs (miRNAs) are critical for neuronal function and their dysregulation is repeatedly observed in neurodegenerative diseases. Here, we implemented high content image analysis for investigating the impact...

    Tal Yardeni, Raquel Fine, Yuvraj Joshi, Tal Gradus-Pery, Noga Kozer… in Scientific Reports (2018)

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  3. No Access

    Article

    Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

    Cultured cell lines are the workhorse of cancer research, but the extent to which they recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here we used multiplexed single-cell R...

    Gabriela S. Kinker, Alissa C. Greenwald, Rotem Tal, Zhanna Orlova… in Nature Genetics (2020)

  4. Article

    Open Access

    PRMT1 inhibition induces differentiation of colon cancer cells

    Differentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. Howe...

    Alexander Plotnikov, Noga Kozer, Galit Cohen, Silvia Carvalho… in Scientific Reports (2020)

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  5. No Access

    Chapter and Conference Paper

    Automatic Calculation of Material Laying Trajectories When Preparing 3D Models for Five-Axis FFF Printing with Continuous Fiber Reinforcement

    The paper outlines the main directions for improving the strength of products in additive manufacturing using FFF technology, and studies methods for preparing control programs for 3D printing for additive man...

    Ilya Gushchin, Ivan Torubarov, Andrey Shvets… in Creativity in Intelligent Technologies and… (2021)

  6. Article

    Open Access

    Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

    Government-sanctioned use of nerve agents (NA) has escalated dramatically in recent years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serv...

    Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar… in Communications Biology (2021)

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  7. No Access

    Article

    A duplex structure of SARM1 octamers stabilized by a new inhibitor

    In recent years, there has been growing interest in SARM1 as a potential breakthrough drug target for treating various pathologies of axon degeneration. SARM1-mediated axon degeneration relies on its TIR domai...

    Tami Khazma, Yarden Golan-Vaishenker… in Cellular and Molecular Life Sciences (2022)

  8. Article

    Correction: A duplex structure of SARM1 octamers stabilized by a new inhibitor

    Tami Khazma, Yarden Golan-Vaishenker… in Cellular and Molecular Life Sciences (2023)

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