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Article
Correction: A duplex structure of SARM1 octamers stabilized by a new inhibitor
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Article
A duplex structure of SARM1 octamers stabilized by a new inhibitor
In recent years, there has been growing interest in SARM1 as a potential breakthrough drug target for treating various pathologies of axon degeneration. SARM1-mediated axon degeneration relies on its TIR domai...
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Article
Open AccessNon-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
Government-sanctioned use of nerve agents (NA) has escalated dramatically in recent years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serv...
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Chapter and Conference Paper
Automatic Calculation of Material Laying Trajectories When Preparing 3D Models for Five-Axis FFF Printing with Continuous Fiber Reinforcement
The paper outlines the main directions for improving the strength of products in additive manufacturing using FFF technology, and studies methods for preparing control programs for 3D printing for additive man...
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Article
Open AccessPRMT1 inhibition induces differentiation of colon cancer cells
Differentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. Howe...
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Article
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Cultured cell lines are the workhorse of cancer research, but the extent to which they recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here we used multiplexed single-cell R...
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Article
Open AccessHigh content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria
microRNAs (miRNAs) are critical for neuronal function and their dysregulation is repeatedly observed in neurodegenerative diseases. Here, we implemented high content image analysis for investigating the impact...
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Article
The nuclear translocation of ERK1/2 as an anticancer target
A hallmark of the ERK1/2 functioning is their nuclear translocation, which is mainly required for the induction of proliferation. Activated ERK1/2 molecules that remain in the cytoplasm initiate other activiti...