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  1. No Access

    Article

    Analysis of the Hypothalamic Orexinergic System in Rats with Different Forms of Genetically Determined Epilepsy

    The hypothalamic orexigenic system was studied in mature males of two rat strains with a genetic predisposition to various forms of epileptic activity: Krushinsky–Molodkina (KM) rats characterized by audiogeni...

    I. Yu. Morina, A. L. Mikhrina… in Journal of Evolutionary Biochemistry and P… (2022)

  2. No Access

    Article

    Assessment of Heat-Shock Protein Hsp70 Colocalization with Markers of Tumor Stem-Like Cells

    The search of biomarkers for early diagnosis and theranostics of glioblastoma multiforme (GBM) due to the aggressiveness of the disease is an urgent needed. In the present work, the expression of the heat-shoc...

    N. M. Yudintceva, A. L. Mikhrina, A. S. Nechaeva, M. A. Shevtsov in Cell and Tissue Biology (2022)

  3. No Access

    Article

    The Role of the AgRP 25-51 Active Fragment in the Regulation of Functional Activity of Locus Coeruleus Norepinephrinergic Neurons and in Norepinephrine Biosynthesis

    Double fluorescence immunolabeling and confocal microscopy showed that the nerve processes immediately surrounding norepinephrinergic (NE) neurons in the brainstem locus coeruleus (LC) are immunopositive to Ag...

    A. L. Mikhrina, L. O. Saveleva… in Journal of Evolutionary Biochemistry and P… (2021)

  4. No Access

    Article

    Immunohistochemical Evidence for the Localization of Dopamine Receptors on Neuropeptide Y-Expressing Neurons in Rat Arcuate Nuclei

    I. V. Romanova, A. L. Mikhrina… in Journal of Evolutionary Biochemistry and P… (2018)

  5. No Access

    Article

    Metabolic parameters and functional state of hypothalamic signaling systems in AY/a mice with genetic predisposition to obesity and the effect of metformin

    The metabolic parameters and functional state of hypothalamic systems in mice with the Yellow mutation in the Agouti locus and with obesity of the melanocortin type and the effect of metformin (MF) treatment (...

    K. V. Derkach, I. O. Zakharova, I. V. Romanova… in Doklady Biochemistry and Biophysics (2017)

  6. No Access

    Article

    Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats

    Using immunofluorescent techniques, we have demonstrated the presence of two main types of dopamine receptors, D1 and D2, on the bodies of neurons of the arcuate nucleus of the hypothalamus expressing the prec...

    I. V. Romanova, A. L. Mikhrina, A. O. Shpakov in Doklady Biological Sciences (2017)

  7. No Access

    Article

    Analysis of development of morphophunctional interconnections between CART- and AGRPergic neurons with dopaminergic structures in ontogenesis of mammals

    Morphogenesis and, probably, formation of structural-functional interaction between the CART- and dopaminergic neurons in rats were found to occur as early as during embryonic development. Meanwhile, formation...

    I. V. Romanova, A. L. Mikhrina… in Journal of Evolutionary Biochemistry and P… (2014)

  8. No Access

    Article

    Participation of agouti-related peptide in the regulation of the wakefulness-sleep cycle

    Agouti-related peptide is expressed in the hypothalamic neurons in humans and animals. Immunohistochemical studies in Wistar rats shows significant changes in the optical density of agouti-related peptide in t...

    I. V. Romanova, A. L. Mikhrina in Human Physiology (2013)

  9. No Access

    Article

    Effect of retinol on interaction of the protein period1, oxytocin, and GABA at the prenatal period of formation of the circadian clock-mechanism in rats

    In mammals, clock-gene proteins are expressed in the neurons of hypot halamic suprachiasmatic nucleus and that of other CNS structures, in the muscles, visceral organs and vessels, thus forming circadian rhyth...

    M. P. Chernysheva, I. V. Romanova… in Journal of Evolutionary Biochemistry and P… (2013)