39 Result(s)
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Article
Modulators of the Nrf2 Signaling Pathway Enhance the Cytotoxic Effect of Standard Chemotherapeutic Drugs on Organoids of Metastatic Colorectal Cancer
The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The...
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Article
Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells....
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Article
Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer
Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia...
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Circulating microRNAs
The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress i...
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Serum Metabolic Profiles of Pregnant Women with Burdened Obstetrical History
The content of low-molecular-weight components in blood serum was studied by tandem mass-spectrometry in pregnant women. Serum metabolic profiles of patients with a grave obstetrical history were detected. The...
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Article
New functions of small nucleolar RNAs
Small nucleolar RNAs (snoRNAs) are one of the most abundant and well-studied groups of non-coding RNAs. snoRNAs are mostly engaged in processing of rRNA. However, recent data indicate that snoRNAs are also inv...
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Article
Changes in Parameters of Laser-Induced Potentials After Transcutaneous Electroneurostimulation
Changes in nerve conduction after 10-min electroneurostimulation of the posterior surface of the neck were studied. Changes in the parameters of laser-induced potentials obtained during stimulation of C7 derma...
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Article
Association of SLC6A4 Gene 5-HTTLPR Polymorphism with Parameters of Simple and Complex Reaction Times and Critical Flicker Frequency Threshold in Athletes during Exhaustive Exercise
The incidence of SLC6A4 gene 5HTTLPR polymorphism alleles was evaluated in 223 male athletes engaged in endurance sports, the results were compared with those in 177 male nonathletes. Association between 5-HTTLPR...
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Article
Exogenous proteins in exhaled human breath condensate
In the course of analysis of protein composition of exhaled breath to diagnose diseases of the respiratory system the problem is raised to distinguish between proteins, expressed in lung tissues and in respira...
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Article
Relationship between Lactate Concentrations in Active Muscle Sweat and Whole Blood
Lactate (lactic acid) concentrations in sweat and venous and capillary blood of athletes were measured before and after exercise of the maximum aerobic power. Correlations between the increment of blood and sw...
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Article
Modulation of α-Rhythm and Autonomic Status of Human by Color Photostimulation
The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: α-rhythm amplitude increases ...
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Article
Short Highly Intense Exercise Causes Changes in Salivary Concentrations of Hydrocortisone and Secretory IgA
The dynamics of salivary hydrocortisone during exercise depends on the professional status of the athlete. Hydrocortisone concentrations increase and those of secretory IgA decrease significantly during short-...
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Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental wo...
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New Aspects of the Influence of Quadriceps Femoris Muscle Stimulation Course on Functional Capabilities of the Organism
We studied the effect of a course of electrical stimulation of the quadriceps femoris muscle with submaximal contraction under biofeedback conditions on functional capabilities of the organism. In addition to ...
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Expression of Early Immune Response Genes during Physical Exercise
Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They ...
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Article
Cross Effect of Electrostimulation of Quadriceps Femoris Muscle during Maximum Voluntary Contraction under Conditions of Biofeedback
We describe cross effect of enhancement of muscular power and electrical activity during electrical stimulation. Due to the use of electrostimulation method with biological feedback and effort visualization fo...
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Article
The human thermal portrait and its relations with aerobic working capacity and the blood lactate level
In a study on 53 healthy male volunteers with the use of an infrared thermograph, data that the thermal portrait, i.e., skin temperature distribution, under the conditions of muscular rest and minimal chemical...
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Article
Prediction of Epitopes in Closely Related Proteins Using a New Algorithm
Latrophilin 1 (presynaptic receptor) binds α-latrotoxin from black widow spider venom and regulates neurotransmitter release from nerve endings. The study of the mechanism of action of this receptor is impeded...
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Article
Application of Mid-Infrared Molecular Spectroscopy for Assessment of Biochemical Parameters of Blood Serum
The method of mid-infrared molecular spectroscopy allows precise measuring of the concentrations of a large number of biological molecules in a minimal sample volume. Method of projections on latent structures...
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Article
Peculiarities of Brain Information Processing in Persons with Different Serotonin Transporter Gene Variants
Association of brain processes presumably underlying aggression with serotonin transporter gene polymorphism in men was studied. Carriers of more active gene variant are characterized by higher aggression inde...
