43 Result(s)

Article

Erratum to: Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study

J. Montonen, H. Boeing, A. Steffen, R. Lehmann, A. Fritsche, H.-G. Joost… in Diabetologia (2012)

Article

Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study

The aim of this study was to prospectively examine the association between body iron stores and risk of type 2 diabetes.

J. Montonen, H. Boeing, A. Steffen, R. Lehmann, A. Fritsche, H.-G. Joost… in Diabetologia (2012)

Article

Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes

Microalbuminuria represents an established surrogate marker of early diabetic nephropathy and glomerular microangiopathy. Increasing evidence is emerging of a role of perivascular adipose tissue (PVAT) as an i...

R. Wagner, J. Machann, R. Lehmann, K. Rittig, F. Schick, J. Lenhart… in Diabetologia (2012)

Article

Body adiposity index, body fat content and incidence of type 2 diabetes

The aim of this study was to compare estimates of body fat content, i.e. body adiposity index (BAI), BMI and waist and hip circumferences, with respect to their ability to predict the percentage of body fat (P...

M. B. Schulze, B. Thorand, A. Fritsche, H. U. Häring, F. Schick, A. Zierer… in Diabetologia (2012)

Article

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in ...

M. Heni, S. Kullmann, C. Ketterer, M. Guthoff, K. Linder, R. Wagner… in Diabetologia (2012)

Article

High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention

Loss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This s...

O. Tschritter, H. Preissl, A. M. Hennige, T. Sartorius, K. T. Stingl… in Diabetologia (2012)

Article

Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women

The objective of our study was to investigate whether changes in BMI during earlier adulthood are more strongly associated with levels of circulating obesity biomarkers in middle age than are BMI changes durin...

J. Montonen, H. Boeing, E. Schleicher, A. Fritsche, T. Pischon in Diabetologia (2011)

Article

Effects of a lifestyle intervention in metabolically benign and malign obesity

We and others recently characterised metabolically benign or healthy obesity (MHO). In the present study we investigated whether a lifestyle intervention is sufficient to place obese insulin-resistant (OIR) in...

K. Kantartzis, J. Machann, F. Schick, K. Rittig, F. Machicao, A. Fritsche… in Diabetologia (2011)

Article

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B

The aim of this study was to investigate the association of the rs10811661 polymorphism near the CDKN2B/CDKN2A genes with glucose tolerance, insulin sensitivity and insulin release in three samples of white peopl...

M. L. Hribal, I. Presta, T. Procopio, M. A. Marini, A. Stančáková… in Diabetologia (2011)

Article

Genetic variants affecting incretin sensitivity and incretin secretion

Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the mol...

K. Müssig, H. Staiger, F. Machicao, H.-U. Häring, A. Fritsche in Diabetologia (2010)

Article

The impact of liver fat vs visceral fat in determining categories of prediabetes

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are risk factors for type 2 diabetes and cardiovascular disease; however, their impact on these endpoints differs. Because liver fat and visc...

K. Kantartzis, J. Machann, F. Schick, A. Fritsche, H.-U. Häring, N. Stefan in Diabetologia (2010)

Article

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

The K121Q (rs1044498) single nucleotide polymorphism (SNP) in the ENPP1 gene has shown association with insulin resistance and type 2 diabetes in various ethnic populations. We hypothesised that K121Q may predict...

K. Müssig, M. Heni, C. Thamer, K. Kantartzis, F. Machicao, N. Stefan… in Diabetologia (2010)

Article

Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity

There is evidence from mouse models and humans that alterations in insulin action in the brain are accompanied by an obese phenotype; however, the impact of insulin with regard to behavioural aspects such as l...

A. M. Hennige, T. Sartorius, S. Z. Lutz, O. Tschritter, H. Preissl, S. Hopp… in Diabetologia (2009)

Article

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

WFS1 type 2 diabetes risk variants appear to be associated with impaired beta cell function, although it is unclear whether insulin secretion is affected directly or secondarily via alteration ...

S. A. Schäfer, K. Müssig, H. Staiger, F. Machicao, N. Stefan, B. Gallwitz… in Diabetologia (2009)

Article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

S. A. Schäfer, O. Tschritter, F. Machicao, C. Thamer, N. Stefan… in Diabetologia (2009)

Article

The risk allele load accelerates the age-dependent decline in beta cell function

Among the novel type 2 diabetes risk loci identified by genome-wide association studies, TCF7L2, HHEX, SLC30A8 and CDKAL1 appear to affect beta cell function. In the present study we examined the effect of these ...

A. Haupt, H. Staiger, S. A. Schäfer, K. Kirchhoff, M. Guthoff, F. Machicao… in Diabetologia (2009)

Article

Diabetes dietary management alters responses to food pictures in brain regions associated with motivation and emotion: a functional magnetic resonance imaging study

We hypothesised that living with type 2 diabetes would enhance responses to pictures of foods in brain regions known to be involved in learnt food sensory motivation and that these stronger activations would r...

M. Chechlacz, P. Rotshtein, S. Klamer, K. Porubská, S. Higgs, D. Booth… in Diabetologia (2009)

Article

Insulin effects on beta and theta activity in the human brain are differentially affected by ageing

O. Tschritter, A. M. Hennige, H. Preissl, Y. Grichisch, K. Kirchhoff… in Diabetologia (2009)

Article

Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction

Different ectopic fat depots, such as visceral or hepatic fat, are known to affect whole body insulin sensitivity. It has recently been hypothesised that differences in perivascular adipose tissue (PVAT) mass ...

K. Rittig, K. Staib, J. Machann, M. Böttcher, A. Peter, F. Schick… in Diabetologia (2008)

Article

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemi...

M. J. Groenewoud, J. M. Dekker, A. Fritsche, E. Reiling, G. Nijpels… in Diabetologia (2008)